基于中医传承辅助平台分析脾胃不和证的处方用药规律  

General Medication Rules in Treating Spleen-stomach Disharmony Based on Traditional Chinese Medicine Inheritance Platform

作　　者：张杰[1] 唐林[1] 葛倩[1] 孟静岩[1] 

机构地区：[1]天津中医药大学,天津300193

出　　处：《世界中医药》2016年第1期159-162,168,共5页World Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)"脾主运化;统血"等脏象理论的继承创新研究(编号:2013CB531701)

摘　　要：目的:分析《中医方剂大辞典》中收录的治疗脾胃不和证的处方用药规律。方法:收集《中医方剂大辞典》中治疗脾胃不和证的方剂,统一和规范药物名称,筛选方剂,录入"中医传承辅助平台"软件(V2.5),采用软件集成的改进互信息法、复杂系统熵聚类、无监督的熵层次聚类等无监督数据挖掘方法,分析脾胃不和证的处方用药的规律。结果:筛选出的186首方剂,涉及175味药物,使用频次>10的药物40味,以性温、味辛、归脾经类药物最多;支持度个数设置为37(20%),得到常用药对及组合21个;熵层次聚类方法,得到用于新方聚类的核心组合34个,聚合成潜在新方17个;含有甘草的方剂共计124首,涉及药物127味,支持度个数设置为74(60%),得到常用药对及核心组合18个。结论:脾胃不和证用药多为补气药、理气药、温中药、化湿药,以性温、味辛、归脾经的药物为主;异功散可作为治疗脾胃不和证的基础方;益气健脾,理气和胃、燥湿化痰、温中散寒为脾胃不和证的核心治法。Objective： To analyze general medication rules in treating spleen-stomach disharmony in Dictionary of Traditional Chinese Medicine Prescriptions. Methods： To collect and filter the prescriptions in Dictionary of Traditional Chinese Medicine Prescriptions,and categorize and standardize the name of Chinese herb. Then input these prescriptions into the traditional Chinese medicine inheritance platform（ V2. 5） and analyze the general medication rule in treating spleen-stomach disharmony by unsupervised data mining methods include improved mutual information method and complex system entropy clustering and unsupervised entropy clustering hierarchy. Results： There were 186 formulas selected and 175 kinds of Chinese herbs were involved. There were 40 kinds of herbs used more than 10 times. Most of them are warm-natured,taste pungent,and attributed to spleen meridian.The numbers of support degree setting is 37（ 20%）,which got 21 herb pairs and combination. Also,thirty-four core combinations which can be used in new prescriptions and 17 potential prescriptions were achieved. A total of 124 prescriptions contain liquorice（ Gancao） were screened out,invo1 ving 127 herbs. Besides,18 herb pairs and core combination were achieved by setting the number of support to 74（ 60%）. Conclusion： The most frequent used drugs in regulating spleen-stomach disharmony are qi-tonifying drugs,qi-regulating drugs,interior-warming drugs,damp-dissolving drugs,and most of which are warm-natured,pungent and be attributive to spleen meridian. Yi Gong San could be used as the basic formula to treat spleen-stomach disharmony. The core treatment method are replenishing qi and invigorating the spleen,regulating qi and harmonizing stomach,drying dampness and resolving phlegm,and warming spleen and dispelling cold.

关 键 词：脾胃不和证 中医传承辅助平台 数据挖掘 用药规律 

分 类 号：R256.3[医药卫生—中医内科学] R311[医药卫生—中医学]