冠心病患者冠脉病变程度与脑钠肽及和肽素水平的相关性  

Coronary lesions in patients with coronary artery disease and the correlation of brain natriuretic peptide and peptide hormones level

作　　者：刘萍 张运[2] 钟敬泉[2] 李曼[2] 

机构地区：[1]新矿集团莱芜中心医院心内科,山东省莱芜市271103 [2]山东大学齐鲁医院心内科,山东省莱芜市271103

出　　处：《中国心血管病研究》2016年第1期18-21,共4页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金面上项目（项目编号：61331001）

摘　　要：目的 探讨冠心病患者病变程度与脑钠肽及和肽素水平之间的关系.方法 选取我院2014年1月至2015年1月确认为冠心病的患者166例,对照者38例.将166例冠心病患者根据病症分为3组,分别为稳定型心绞痛组、不稳定型心绞痛组和心肌梗死组;以38例对照者为对照组.检测并比较四组受检者的血浆脑钠肽及和肽素水平;比较四组受检者的冠状动脉左主干的病变程度、病变支数、冠状动脉的Gensin评分与脑钠肽水平的相关性.结果 稳定型心绞痛组的Gensini评分为（10.2±1.7）,不稳定型心绞痛组的Gensini评分为（32.2±3.9）,心肌梗死组的Gensini评分为（33.3±4.2）.四组受检者的脑钠肽及和肽素水平比较差异均具有统计学意义（P＜0.05）,且心肌梗死组脑钠肽及和肽素水平与不稳定型心绞痛组比较差异具有统计学意义（P＜0.05）.不稳定型心绞痛组患者脑钠肽及和肽素水平与其Gensini评分呈正相关,分别为0.512与0.573,心肌梗死组患者脑钠肽及和肽素水平与其Gensini评分呈正相关,分别为0.525与0.632,此两组与稳定型心绞痛组比较差异均有统计学意义（P＜0.05）.结论 冠心病患者血浆脑尿钠肽及和肽素水平与其冠状动脉病变有一定相关性,能够正确反映冠心病患者的心肌受损程度,对于临床治疗具有指导意义.Objective To explore the relationship between the degree of pathological changes of coronary heart disease（CHD） patients and the levels of brain natriuretic peptide and the peptide hormones. Methods 166 cases of coronary heart disease patients admitted in our hospital between January 2014 and January 2014 were en- rolled, and 38 health eases were chosen as control group. 166 eases of coronary heart disease patients were divid- ed into stable angina（SAP）, unstable angina（UAP） and myocardial infaretion（AMI group ）. The plasma brain na- triuretic peptide （BNP） and peptide hormones levels were measured and compared among the four groups. The re- lationship between BNP and the degree of left main coronary artery lesions, the numbers of lesion, Gensin score. Results Gensini scores were （10.2±1.7）, （32.2±3.9） and （33.3±4.2） in stable angina pectoris group, unstable angina pectoris group and myocardial infarction group respectivdy. The levels of brain natriuretic peptide and pep- tide hormones were statistically significant different （P〈0.05） among four group. Brain natriuretic peptide in pa- tients with unstable angina group and peptide hormones levels were positively correlated with Gensini score（0.512 and 0.573, respectively）, brain natriuretic peptide in patients with myocardial infarction group and peptide hor- mones levels were positively correlated with Gensini score （0.525 and 0.632, respectively）, the two groups com- pared with stable angina pectoris group differences were statistically significant （P〈0.05）. Conclusion The coro-nary heart disease patients plasma brain urine sodium peptide and peptide hormones levels and patients of coronary artery lesions has certain relevance, can correctly reflect the degree of myocardial damage in patients with coro- nary disease.

关 键 词：冠状动脉疾病 冠脉病变程度 脑钠肽 和肽素 

分 类 号：R541.4[医药卫生—心血管疾病]