血栓调节蛋白水平与冠心病关系的研究  

Study on association between thrombomdulin level and coronary heart disease

作　　者：陈聿峰[1] 罗骏超 覃方生 韦曙平 

机构地区：[1]广西科技大学第二附属医院心内科,广西壮族自治区柳州市545006

出　　处：《中国心血管病研究》2016年第1期26-29,共4页Chinese Journal of Cardiovascular Research

基　　金：广西壮族自治区卫生厅自筹经费科研课题（项目编号：Z2014018）

摘　　要：目的 探讨血栓调节蛋白（TM）水平与冠心病（CHD）的相关性.方法 81例CHD患者（CHD组）均在我院确诊;57例健康体检者为对照组.CHD组及对照组均来自我院2014年1月至2015年7月住院患者及门诊体检者.CHD组男性48例,女性33例,平均年龄（58.2±7.2）岁;对照组男性31例,女性26例,平均年龄（53.9±6.9）岁.均采用酶联免疫吸附法（ELISA）检测外周血浆TM水平,比较两组TM水平差异;多元线性回归分析冠心病危险因素对TM的影响;Pearson相关分析TM水平与动脉硬化指数的关系;受试者工作特征曲线（ROC曲线）分析TM对CHD诊断价值.结果 CHD组TM为（53.99±15.39）μg/L,对照组为（48.11±12.09）μg/L,CHD组TM水平明显高于对照组（P＜0.05）.TM水平与动脉硬化指数存在正相关（r=0.28,P＜0.05）;ROC曲线下面积为0.596,面积的95％CI0.498～0.694,TM判断CHD无显著意义（P=0.056）.结论 CHD患者TM水平明显升高,但单独TM升高对判断CHD无显著意义.Objective To investigate the relationship between thrombomdulin （TM） and coronary heart disease（CHD）. Methods 81 patients with CHD（CHD group） were diagnosed in our hospital, 57 cases of healthy physical examination as the control group. The two group were enrolled from 2014.1 to 2015.7. The CHD group were 48 male cases, 33 female cases, average age （58.2±7.2）years. There were 31 cases of male, female 26 cas- es, average age（ 53.9±6.9 ）years in control group. The TM level was detected by enzyme-linked immunosorbent as- say （ELISA）. TM levels were compared between the two groups. The effect of risk factors of coronary heart disease on TM were analyzed by multiple linear regression. The relationship between TM levels and arterial stiffness index were analyzed by Pearson correlation. The significance of TM in the diagnosis of CHD was analyzed by receiver op- erating eharacteristie（ROC curve）. Results TM was （53.99±15.39）μg/L in the CHD group and （48.11±12.09） μ g/L in the control group. The level of TM in CHD group was significantly higher than that in control group （P〈 0.05 ）. There was positively correlation between TM levels and arterial stiffness index （r=0.28,P〈0.05）. The area under the ROC curve was 0.596, and the area of 95%CI 0.498-0.694. TM has no significant value in judging CHD（P=0.056）. Conclusion The level of TM in patients with CHD is significantly increased, but it has not sig- nificantly value in the diagnosis of CHD.

关 键 词：冠状动脉疾病 血栓调节蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]