血清抗M型磷脂酶A_2受体抗体与成人特发性膜性肾病危险性的相关性研究  

The correlation of anti-phospholipase A_2 receptor antibodies with idiopathic membranous nephropathy in adult

作　　者：刘延[1] 杨小娟[1] 

机构地区：[1]延安大学附属医院肾内科,延安716000

出　　处：《陕西医学杂志》2016年第4期395-396,共2页Shaanxi Medical Journal

基　　金：陕西省延安市科学技术研究发展计划项目(2012KW-12)

摘　　要：目的:探讨血清中抗M型磷脂酶A2受体抗体和成人特发性膜性肾病的相关性,以及抗体滴度和患者严重程度的关系。方法:本次研究收集了128例患者,半定量检测被试者血清中抗M型磷脂酶A2受体抗体,定量检测被试者血清中抗M型磷脂酶A2受体抗体。结果:血清中抗M型磷脂酶A2受体抗体在特发性膜性肾病病人血液中特异性存在,完全缓解和部分缓解患者血清中抗M型磷脂酶A2受体抗体明显减少。结论:血清中抗M型磷脂酶A2受体抗体的存在或许可作为成人特发性膜性肾病的生物学标记物并用于评估病情。Ohiective： To assess the correlation between Anti-M-type receptor of secretory phospholipase A2 and idiopathic membranous nephropathy. Methods： This study collected 128 cases from2010 to 2015 and detect Anti-M-type receptor of secretory phospholipase A2. Results： Anti-M-type receptor of secretory phosphoIipase A2 can be detected in patients＇ serum instead of normal people. And in recovered patients, the amount of anti-M-type receptor of secretory phospholipase A2 decreased obviously. Conclusion： Anti-M-type receptor of secretory phospholipase A2 may be a biomarker of idiopathic membranous nephropathy, and it may also be used to evaluate patients＇ condition.

关 键 词：肾小球肾炎 膜性 @抗M型磷脂酶A2受体抗体 

分 类 号：R692.6[医药卫生—泌尿科学]