原发性醛固酮增多症与原发性高血压腹主动脉粥样硬化斑块特征的初步比较  

Preliminary Comparison of Abdominal Atherosclerotic Plaque Characteristics between Patients with Primary Aldosteronism and Essential Hypertension

作　　者：冯雷雨[1,2] 高明[3] 高静伟[1,2] 黄辉[1,2] 刘品明[1,2] 

机构地区：[1]中山大学孙逸仙纪念医院心内科,510120 [2]广东省心电生理与心律失常重点医学实验室 [3]中山大学孙逸仙纪念医院放射科

出　　处：《岭南急诊医学杂志》2016年第1期45-47,共3页Lingnan Journal of Emergency Medicine

基　　金：国家自然科学基金(81370837;81170647);广东省战略性新兴产业省级核心攻关项目(2012A080800007)

摘　　要：目的:比较原发性醛固酮增多症(PA)和原发性高血压(EH)患者腹主动脉粥样硬化(AS)斑块发生率和斑块体积,探讨PA患者AS发生发展的可能危险因素。方法:选择2012年7月1日至2015年7月1日期间因"高血压查因"住院确诊的资料完整的43例PA患者与同期确诊的年龄、性别、高血压水平及其病程等相匹配的43例EH患者为研究对象,采用64排螺旋CT检测和定量评估两组患者腹主动脉AS斑块。结果:PA患者较EH患者具有更高AS斑块发生率(62.8%vs.32.6%,P<0.05),PA患者AS斑块体积高于EH组(P<0.05)。年龄、血清低密度脂蛋白胆固醇(LDL-C)水平、醛固酮/肾素比值(ARR)与粥样斑块体积呈正相关(P<0.05)。结论 :PA患者较EH患者具有更严重的AS,年龄、LDL-C、ARR与PA患者AS的发生密切相关。Objective：To compare the volume of abdominal aortic atherosclerotic plaque between patients with primary aldosteronism（PA） and essential hypertension（EH）, and to explore the risk factors of atherosclerosis（AS）in PA patients. Methods：Forty-three PA cases and 43 EH controls matched for age, sex, blood pressure and duration of hypertension were enrolled in this study. Sixty-four-slice multidetector computed tomography（MDCT） was performed to quantify abdominal aortic atherosclerotic plaque in all patients. Results： The prevalence and volume of abdominal aortic atherosclerotic plaque were significantly higher in PA cases than in EH controls（all P〈0.05）. The correlation coefficient between serum aldosterone-to-renin ratio, LDL-C, age and plaque volumes was 0.417, 0.315 and 0.728respectively（all P〈0.05）. Conclusion： Patients with PA have more severe AS than EH patients, and the serum LDL-C level, aldosterone-to-renin ratio and age are significantly associated with AS.

关 键 词：原发性醛固酮增多症 高血压 斑块 动脉粥样硬化 

分 类 号：R544.11[医药卫生—心血管疾病] R586.24[医药卫生—内科学]