COMT基因多态性与子宫内膜增生易感性的关系  

Relation between Polymorphism of Catechol-O-methyltransferase Gene and the Genetic Risk of Endometrial Hyperplasia among the South China Women

作　　者：郝梅花 赵晓苗[1] 杨冬梓[1] 晋晨晨 谢梅青[1] 

机构地区：[1]中山大学孙逸仙纪念医院妇产科,510120 [2]中山大学中山医学院,510080

出　　处：《岭南急诊医学杂志》2016年第1期52-55,共4页Lingnan Journal of Emergency Medicine

基　　金：国家自然科学基金面上项目(81471425);广东省自然科学基金(2015A030313091)

摘　　要：目的:探讨参与雌激素分解代谢的儿茶酚-O-甲基转移酶(catachol-O-methyltransferase,COMT)的基因多态性与子宫内膜增生发生风险的关系。方法:以多聚酶链反应-限制性片段长度多态性法对100例子宫内膜增生患者和110例对照者的COMT基因第4外显子第158位密码子G/A的多态性进行分析,用非条件logistic回归分析COMT基因多态性与子宫内膜增生的遗传易感性的关系。结果:两组的COMT基因型分布频率无统计学差异(P>0.05),皆以COMTVal/Val基因型为主(47.3%)。经Logic回归分析,与COMTMet/Met基因型相比,COMTVal/Val基因型的优势比(OR)=0.988(95%CI=0.137-7.116),COMTVal/Met基因型的OR值=0.656(95%CI=0.094-4.582)。结论:COMT基因多态性与中国南方女性子宫内膜增生过长发生风险无相关性,COMTMet/Met基因型不增加患子宫内膜增生的风险。Objective： To examined whether polymorphism of COMT involved in estrogen metabolism was associated with endometrial hyperplasia genetic risk. Methods： Polymerase-chain reaction-restrictive fragment length polymorphism（PCR-RFLP） analysis was used to study the variant allele frequency distributions of COMT val 158-met genetic polymorphism in a population based case-control study with 100 endometrial hyperplasia patients and 110 control women. Odds ratios（ORs） and 95% confidence intervals（95% CI） were estimated by unconditional logistic regression to analysis the susceptibility of endometrial hyperplasia. Results： The difference between endometrial hyperplasia and control groups was of no statistical significance; and COMTVal / Val genotype was the most（47.2%）.Compared with COMTMet / Met genotype, neither COMTVal / Val nor COMTVal / Met genetype was correlated with endometrial hyperplasia risk. The adjusted OR value was 0.988（95%CI=0.137-7.116） and 0.656（95%CI=0.094-4.582） respectively. Conclusion： Among the South Chinese women, there was no difference between two groups on the distribution of genotype frequency and no relation between COMT genetic polymorphism and endometrial hyperplasia. The allele encoding for low activity COMT did not increase the susceptivity of endometrial hyperplasia.

关 键 词：子宫内膜增生 儿茶酚-O-甲基转移酶 单核苷酸多态性 雌激素代谢 

分 类 号：R711.74[医药卫生—妇产科学]