舌下免疫治疗成人季节性变应性鼻炎的疗效和安全性Meta分析  

Therapeutic efficacy and safety of sublingual immunotherapy in treatment of adults with seasonal allergic rhinitis: a meta-analysis

作　　者：赵辉[1] 江洪[1,2] 龙宇[1] 罗玉杰[1] 

机构地区：[1]重庆医科大学附属永川医院耳鼻咽喉头颈外科,重庆永川402160 [2]重庆医科大学附属永川医院听觉言语研究室,重庆永川402160

出　　处：《局解手术学杂志》2016年第4期292-297,共6页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的系统评价舌下免疫治疗(SLIT)在成人季节性变应性鼻炎(SAR)中的疗效及安全性。方法计算机检索CNKI、CBM、维普、万方、Pub Med、EMBase、Medline、Cochrane图书馆等数据库,收集舌下免疫治疗成人SAR的随机对照试验(RCT)。由2位研究者按照纳入与排除标准独立筛选文献、提取资料和评价质量后,采用Rev Man 5.2软件进行Meta分析。结果共纳入13个RCT。Meta分析结果显示,在降低成人SAR患者症状评分(SS)及药物评分(MS)方面,SLIT与安慰剂比较具有显著优势,差异具有统计学意义(P<0.000 01);SLIT组与安慰剂组相比,不良事件发生率高,常见的不良反应有口腔瘙痒、口腔水肿、耳部瘙痒、咽喉不适等。结论舌下免疫治疗成人SAR可以显著改善SAR患者的症状,降低药物评分,且其安全性是可以接受的。Objective To systematically investigate the efficacy and safety of sublingual immunotherapy（ SLIT） in the treatment of adults with seasonal allergic rhinitis（ SAR）. Methods Literature was retrieved online in CNKI,CBM,VIP,Wanfang data,Pub Med,EMBase,Medline,Cochrane Library,et al. After screening literature,data collection and assessment quality,randomized controlled trials relevant to our study were selected independently based on inclusion and exclusion criteria by two researchers. Statistical analyses were conducted by Rev Man5. 2 software. Results A total of 13 RCTs were enrolled. The meta-analysis revealed that SLIT provided a significant improvement in aspect of reducing Symptom Scores（ SS） and Medication Scores（ MS） of adults with SAR,the difference had statistical significance（ P〈0. 000 01）.Compared to placebo,SLIT could increase the rate of adverse events（ AEs） in the treatment of adults with SAR compared to placebo. The frequently reported AEs during clinical trials were oral pruritus,tongue edema,ear pruritus,throat irritation,et al. Conclusion Sublingual immunotherapy could improve the symptoms significantly and reduce the SS and MS in the treatment of adults with SAR. And its safety could be well tolerated.

关 键 词：舌下免疫治疗 季节性变应性鼻炎 花粉症 疗效 安全性 META分析 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]