急性腹腔感染血清内源性H_2S水平的变化及临床意义  

Level changes and clinical significance of endogenous H2S of patients with acute abdominal infection

作　　者：陈刚[1] 李鹤[2] 王丹[2] 赵和照[1] 刘浩[2] 

机构地区：[1]重庆市肿瘤研究所胃肠外科,重庆400030 [2]西安交通大学医学院第一附属医院普通外科,陕西西安710061

出　　处：《中国现代普通外科进展》2016年第3期202-204,208,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨急性腹腔感染患者内源性硫化氢(H2S)水平的变化及其临床意义。方法:采集单纯腹腔感染患者(观察组,28例)和健康体检者(对照组40例)静脉血液,用去蛋白法比较两组内源性H2S水平变化。结果:观察组与对照组内源性H2S水平分别为(51.27±4.90)μmol/L和(34.05±2.90)μmol/L,差异有统计学意义(P<0.05);观察组感染控制前后内源性H2S水平分别为(51.27±4.90)μmol/L、(37.26±3.20)μmol/L,差异有统计学意义(P<0.05);随着APACHEⅡ评分的升高,观察组内源性H2S水平亦升高,差异有统计学意义(P<0.05)。结论:内源性H2S参与腹腔感染炎症反应过程并可能成为提示腹腔感染严重程度的血清学指标。Objective： To research the level changes and clinical significance of endogenous hydrogen sulfide of patients with acute abdominal infection. Methods： Blood（2 m L）was collected,and the levels of serum H_2S was measured through deproteinate method. The levels of endogenousH2S were compared between patients with abdominal infection and non abdominal infection. We also compared the levels of H_2S in patients before and after the abdominal infection were controled,and the levels of H_2S in patients with varying degrees of infection. Results： The concentration of endogenous H_2S of patients with abdominal infection and non abdominal infection were（51.27±4.90）μmol/L and（34.05±2.90）μmol/L（P0.05）;The concentration of H_2S in patients before and after the abdominal infection were controlled were（51.27±4.90）μmol/L and（37.26±3.20）μmol/L（P0.05）; Along with APACHEⅡ score increasing of patients with infection,the concentration of endogenous H_2S were also increased. When the APACHEⅡ score were 5~10（n=6）,the concentration of endogenous H_2S was（43.73±1.56）μmol/L, When the APACHEⅡ score were10~15（n=13）, the concentration of endogenous H_2S was（51.31±2.29）μmol/L, When the APACHEⅡ score were 15~20（n=9）, the concentration of endogenous H_2S was（56.23±1.21）μmol/L（P0.05）. Conclusion： The level of endogenous H_2S were increasing along with the infection occurrencing and the gradient of infection aggravating. We can presume that endogenous H_2S may be involved in the inflammatory reaction of the abdominal infection and may become a serological indicator of the severity of the infection.

关 键 词：腹腔感染 硫化氢 

分 类 号：R656.1[医药卫生—急诊医学]