流动注射化学发光法测定醋氯芬酸  

Determination of Aceclofenac by Flow Injection Chemiluminescence Method

作　　者：刘欢[1] 张琰图[1] 双海军[1] 宋馥馨 

机构地区：[1]延安大学化学与化工学院,陕西延安716000

出　　处：《分析测试学报》2016年第4期497-500,共4页Journal of Instrumental Analysis

基　　金：陕西省高水平大学建设专项资金(2013SXTS03);延安大学重点自然科学基金项目(YD2014-06);延安市科技创新团队项目(2015-08)

摘　　要：基于酸性条件下醋氯芬酸对高锰酸钾氧化甲醛产生微弱化学发光反应体系具有很强的增敏作用,且增强的发光强度在一定范围内与醋氯芬酸浓度呈良好的线性关系,结合流动注射分析技术,建立了测定醋氯芬酸的化学发光新方法。该法测定醋氯芬酸的线性范围为0.08-5.0 mg/L,检出限（3σ）为3.0×10^（-2）mg/L,相对标准偏差（RSD）为1.7%（n=11,c=0.50 mg/L）,回收率为98.1%-104.6%。该法已用于片剂和胶囊中醋氯芬酸含量的测定。A novel chemiluminescence method for the determination of aceclofenac was developed,based on the fact that aceclofenac could enhance the chemiluminescence intensity from the reaction of potassium permanganate with formaldehyde in acidic medium.The experiments indicated that under optimum conditions,the enhanced intensity of chemiluminescence was linearly related to the concentration of aceclofenac in the range of 0.08-5.0 mg / L with a detection limit（3σ） of 3.0 × 10^-2mg /L.The relative standard deviation（RSD） was 1.7% for 0.50 mg / L aceclofenac solution in 11 repeated measurements.The method was successfully applied in the determination of aceclofenac in the tablets and capsules with recoveries of 98.1%-104.6%.

关 键 词：流动注射 化学发光 醋氯芬酸 高锰酸钾 

分 类 号：O657.3[理学—分析化学] TQ460.72[理学—化学]