卵泡发育过程中的Wnt信号通路  

Wnt Signal Pathway during Folliculogenesis

作　　者：周团萍 崔毓桂[1] 千日成[1] 

机构地区：[1]南京医科大学第一附属医院生殖医学科,210029

出　　处：《国际生殖健康／计划生育杂志》2016年第2期128-131,共4页Journal of International Reproductive Health/Family Planning

基　　金：国家自然科学基金(81370764);国家973项目(2012CB944703);江苏省卫生厅项目(ZX201110);江苏省妇幼保健重点学科(FXK201221)

摘　　要：Wnt蛋白与细胞膜上相应受体结合,引起胞质中β-catenin集聚并向核内转移,激活下游相关靶基因的转录。该信号通路是调节卵泡生长发育的一个关键途径。Wnt2影响β-catenin的细胞定位来调节颗粒细胞的增殖;Wnt4是一个多功能因子,在卵泡发育的许多阶段都有表达并通过多种途径来调节卵泡的生长、发育和成熟。受体Fzd1调节卵丘扩展相关因子的表达。β-catenin还参与合成卵巢甾体激素和黄体的生成。该通路受损时,会引起卵巢早衰、诱发颗粒细胞肿瘤、排卵障碍和黄体功能不足等。阐述经典的Wnt信号通路及其在调节卵泡发育过程中的作用及其分子机制。The transduction of Wnt signal involves the interaction between Wnt and Fzd as well as cooperation with single-pass co-receptors,which induces the β-catenin translocation to nucleus and the transcription of target genes. This Wnt pathway drives the proliferation of granulosa cells via the intracellular β-catenin translocation. Wnt4 is a pleiotropic player during prenatal and postnatal follicular development,maturation and survival. Fzd1 participates in regulating the expression of those genes involved in cumulus expansion. β-catenin also participates in steroidogenesis and luteogenesis. The maladjustment of β-catenin may lead to premature ovarian failure,granulosa cell tumors and luteal phase defects. In this review,we summarized the classical Wnt/β-catenin pathway and its roles in folliclogenesis.

关 键 词：信号传导 卵泡 甾类 激素类 排卵 黄体形成 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]