薄型子宫内膜治疗新进展  

Treatment of Thin Endometrium:A Brief Review

作　　者：俞凌[1] 王淑芳[1] 叶明侠[1] 左昭[1] 姚元庆[1] 

机构地区：[1]中国人民解放军总医院,北京100038

出　　处：《国际生殖健康／计划生育杂志》2016年第2期165-169,共5页Journal of International Reproductive Health/Family Planning

基　　金：中国博士后科学基金(2015M572765)

摘　　要：子宫内膜过薄会导致子宫内膜容受性降低,从而影响胚胎植入,最终使妊娠率降低。目前为止,虽有多种方法应用于该病的治疗,但仍没有一种普遍适用并获得确切疗效的方法,所以薄型子宫内膜的治疗仍是一项重大挑战。薄型子宫内膜的治疗方法主要包括:激素治疗、改善血管活性药物(阿司匹林、维生素E、己酮可可碱、L-精氨酸、西地那非)的治疗、宫腔内粒细胞集落刺激因子(G-CSF)灌注和最近兴起的再生医学。通过评估多种治疗方法对子宫内膜厚度的改善效果以及内膜再生情况,可以对薄型子宫内膜的治疗有更为全面的了解,发现更有优势的研究方向,综合管理因内膜因素导致不孕的患者,有序地应用个体化治疗方法,改善内膜厚度,提高妊娠率。Thin endometrium can cause unsuitable endometrial receptivity,affect the embryo implantation,and ultimately reduce the pregnancy rate. A variety of methods have been tried to treat this disease so far.However,there is not a universal method with the exact efficacy,which means that the treatment of thin endometrium is still a challenge for clinician. Several treatment modalities have been offered to patients with thin endometrium,including the endometrial local micro-injury,hormones（estrogen and Gn RH-agonist）,vasoactive medicines（aspirin,vitamin E,pentoxifylline,L-arginine and sildenafil）,intrauterine infusion of G-CSF and the new clinical trial of regenerative medicine. We reviewed and compared those treatments of thin endometrium,so as to provide a reference for clinician to treat individually patients by improving endometrial receptivity,increasing the pregnancy rate,and optimizing patient management.

关 键 词：薄型子宫内膜 生殖技术 辅助 再生医学 妊娠率 

分 类 号：R711.74[医药卫生—妇产科学]