重型肝炎患者医院真菌感染相关因素分析  

Related factors of nosocomial fungal infections in patients with severe hepatitis

作　　者：荆会霞 赵宁[1] 王俊梅[1] 俞玲[1] 王明娟[1] 

机构地区：[1]郑州人民医院消化内科,河南郑州450003

出　　处：《中华医院感染学杂志》2016年第7期1551-1553,共3页Chinese Journal of Nosocomiology

基　　金：河南省科技攻关基金资助项目(2014206115)

摘　　要：目的探讨重型肝炎患者医院真菌感染情况,并总结预防感染的措施,以降低感染率。方法选择2013年1月-2013年12月收治的120例重型肝炎患者医院真菌感染为感染组,另选择100例重型肝炎无真菌感染患者为非感染组,观察并记录患者临床症状,对感染组患者进行真菌培养,探究重型肝炎患者医院真菌感染的临床特征及预防控制措施,数据采用SAS 9.3软件进行统计分析。结果 120例重型肝炎医院真菌感染主要感染部位为腹腔和胃肠道,分别占36.99%、25.34%;共分离出真菌141株,以白色假丝酵母菌为主,共110株占78.01%;多因素分析显示,住院时间长、抗菌药物使用种类多、接受侵入性操作治疗、合并并发症是重型肝炎患者并发医院感染的独立危险因素(P<0.05)。结论应加强对重型肝炎医院真菌感染患者的预防和控制,以降低感染的发生率。OBJECTIVE To investigate the nosocomial fungal infections in patients with severe hepatitis and summarize the measures to prevent infections so as to reduce the infection rate.METHODS Totally 120 cases of patients with severe hepatitis and subsequent nosocomial fungal infections（infected groups）and 100 cases of patients with no subsequent nosocomial fungal infections（non-infected groups）during Jan.2013 to Dec.2013 were selected.The clinical symptoms were observed and recorded and fungal culture was given for patients in the infected group to explore the clinical features and prevention measures of patients with severe hepatitis and subsequent nosocomial fungal infections.Data were statistically analyzed by software SAS 9.3.RESULTS Totally 120 cases of patients with severe hepatitis and subsequent nosocomial fungal infections found that the main infection sites were abdominal and gastrointestinal tract,accounting for 36.99%,25.34%.A total of 141 strains of fungi were found by fungal culture,and the main infection bacteria were Candida albicans（110strains,accounting for 78.01%）.The logistics regression showed that long time of hospital stay（OR=9.12）,various types of antibiotic use（OR=7.26）,invasive operation therapy（OR=14.39）and combined diseases（OR=5.33）were the independent risk factors for severe hepatitis patients to develop nosocomial infections.CONCLUSIONStrengthened measures should be given to prevent and control nosocomial fungal infections to reduce the incidence of infections.

关 键 词：重型肝炎 真菌感染 危险因素 预防 控制 

分 类 号：R512.6[医药卫生—内科学]