小儿脑瘫、精神发育迟滞、癫痫与弓形虫感染关系的研究  

A Study of Relationship Between Cerebral Palsy, Mental Retardation, Epilepsy and Toxoplasma Infeotion in Children

作　　者：陈听安[1] 陆雪芬[1] 吕冰清[2] 

机构地区：[1]广州医学院附二院神经研究所 [2]湖南医科大学

出　　处：《中国人兽共患病杂志》1991年第5期7-9,共3页Chinese Journal of Zoonoses

摘　　要：本文同时采用3种血清学方法检测了210例不明原因的脑瘫、精神发育迟滞和癫痫患儿及100例正常小儿血清和部分患儿脑脊液弓形虫抗体。结果表明:脑瘫和精神发育迟滞弓形虫感染率分别为41.3％和38.6％,明显高于对照组(14％)(P<0.01),提示弓形虫感染是不明原因的脑瘫和精神发育迟滞的重要病因之一;癫痫组弓形虫感染率为18.3％,与对照组比较差别无显著性,似提示弓形虫感染可能与该组癫痫关系不大。在弓形虫抗体阳性患儿中,抗体效价多偏低,仅提示过去感染。患儿血中弓形虫抗体与其脑脊液中抗体之间有相关性。210 patienta with cenebral palsy or mental retsrdation or epilepsy, and 100 normal children as control group have been studied for toxoplasma inrection by indirect bemagglutination test (IHA), indirect flurenscent antibody test (IFA) and enzyme-linked immunosorbent assay test (ELISA) . The results showed that sera prevalence of toxoplasma antibody of cerebral palsy and mental redardation were 41. 3%, 38. 6%, respectively, and werfc significantly higher than that of the control(14%),which indicated that toxoplasma infection might be one of the important causes in etiology for cerebral palsy and mental redardation; and which showed no significant difference that there was riot much relationship between toxoplasma infection and epilepsy. In most of the antibody-positive patients, the titres were low, suggesting that the infections were in the past. The patients' toxoplasma antibodies in serum were relative to that in cerebrospinal fluid.

关 键 词：弓形体病 脑瘫 精神发育迟滞 癫痫 

分 类 号：R531.802[医药卫生—内科学]