卟啉纳米技术:探索生物光子学新视角  

Porphysome Nanotechnology:Explore New Frontiers of Biophotonics and Beyond

作　　者：郑岗 

机构地区：[1]多伦多大学医学生物物理学系

出　　处：《光学与光电技术》2016年第2期1-5,共5页Optics & Optoelectronic Technology

摘　　要：我们最新发现了卟啉纳米,第一种集多种功能与优良光学特性于一身、全部有机的纳米颗粒。这种纳米颗粒通过卟啉脂质自组装形成一个约100nm的类脂质体结构,该颗粒上极高的卟啉密度(>80 000每颗粒)使其能够高效吸收光能并转换成热能,成为理想的光热治疗以及光声成像的载体,也能够进行荧光成像以及光动力治疗。此外,卟啉纳米也可通过螯合金属离子进行PET和MRI成像。通过改变卟啉脂质组装,开发了一系列不同尺寸和生物光学功能的卟啉纳米和微米颗粒,如卟啉纳米碟、卟啉纳米微泡、卟啉微反应器、卟啉-金纳米颗粒等。有别于传统"搭积木"式的多功能纳米载体,卟啉纳米内在的多功能特性和超简单的结构代表了一种全新的纳米颗粒设计概念,具有临床转化的前景。We recently discovered ‘porphysomes＇,the first all-organic nanoparticles with intrinsic multimodal photonic properties.They are self-assembled from porphyrin-lipid building blocks to form liposome-like bilayer vesicle（~100nm diameter）.The very high porphyrin packing density（〉80 000 per particle）results in both‘super＇-absorption and structuredependent‘super＇-quenching,which,in turn,converts light energy to heat with extremely high efficiency,giving them ideal photothermal and photoacoustic properties.Upon porphysome nanostructure dissociation,fluorescence and photoreactivity of free porphyrins are restored to enable low background fluorescence imaging and activatable photodynamic therapy.In addition,metal ions can be directly incorporated into the porphyrin building blocks of the preformed porphysomes thus unlocking their potential for PET and MRI.By changing the way porphyrin-lipid assembles,we developed porphyrin nanodisc（〈20nm）,trimodal（US/photoacoustic/fluorescence）porphyrin shell microbubbles（~2μm）,microscopy-controlled porphyrin protocells（~100μm）,and hybrid porphyrin-gold nanoparticles,expanding the purview of porphyrin nanophotonics.Compared with classical＂all-in-one＂nanoparticles containing many functional modules,the simple yet＂one-for-all＂nature of porphysomes represents a novel approach to the design of multifunctional nanoparticle and confers high potential for clinical translation.

关 键 词：光热治疗 光声成像 荧光成像 光动力治疗 正电子发设型计算机断层显像 核磁共振成像 临床转化 

分 类 号：TB383[一般工业技术—材料科学与工程]