亚临床甲状腺功能减退症与2型糖尿病早期肾损伤的相关性  

Correlation between subclinical hypothyroidism and early renal injury in type 2 diabetes mellitus

作　　者：张梅[1] 贾农[1] 赵晓丽[2] 张鸿青[3] 胡大春[2] 

机构地区：[1]昆明市第一人民医院内分泌科,云南昆明650011 [2]昆明市第一人民医院检验科,云南昆明650011 [3]昆明市第一人民医院心内科,云南昆明650011

出　　处：《云南医药》2016年第2期167-169,共3页Medicine and Pharmacy of Yunnan

摘　　要：目的探讨亚临床甲状腺功能减退症与2型糖尿病肾损伤的相关性。方法选择尿常规检查尿蛋白阴性2型糖尿病(T_2DM)患者436例,按促甲状腺激素水平,分为单纯糖尿病组352例(男190例,女162例);糖尿病伴亚临床甲减组84例(男28例,女56例)。观察两组间尿白蛋白/肌酐比值(UACR)、肾小球滤过率估计值(e GFR)、血肌酐(Scr)的变化。结果糖尿病伴亚临床甲减组与单纯糖尿病组UACR、e GFR两项肾功能指标比较,差异有统计学意义(P<0.01)。Logistic分析TSH是UACR升高的危险因素,OR为1.175。而不是e GFR降低的危险因素。UACR与TSH呈正相关(r=0.180,P=0.00)。结论亚临床甲减增加了2型糖尿病患者早期肾脏损伤。Objective To investigate the relationship between subclinical hypothyroidism and type 2 diabetic renal injury. Methods To select the 436 cases of urinary protein negative type 2 diabetes mellitus（T2DM）, and divide into simple DM 352 cases（male 190 cases, female 162 cases） and diabetes mellitus with subclinical hypothyroidism group 84 cases（male 28, female 56） according to the level of thyroid stimulating hormone. To observe the changes of urinary albumin/creatinine ratio（UACR）, estimated glomerular filtration rate（e GFR）, and serum creatinine（Scr）in the two groups. Results The differences of UACR and e GFR in the two groupes were statistically significant（P〈0.01）.Due to logistic analysis, TSH is a risk factor for the increase of UACR（OR is 1.175）. UACR and TSH were positively correlated（r=0.180,P=0.00）. Conclusion Subclinical hypothyroidism in type 2 diabetic patients increases early renal injury.

关 键 词：糖尿病 亚临床甲状腺功能减退症 肾损伤 

分 类 号：R587.1[医药卫生—内分泌]