中药糙苏中的环烯醚萜类化合物  

Iridoid compounds from Phlomis umbrosa of herb medicine

作　　者：曹轲[1] 丁明明[2] 庄方方[1] 殷田田 闫福林[1] 

机构地区：[1]新乡医学院药学院,河南新乡453003 [2]南阳市中心医院药学部,河南南阳473009

出　　处：《新乡医学院学报》2016年第3期164-168,共5页Journal of Xinxiang Medical University

基　　金：国家自然科学基金资助项目(编号:81172953)

摘　　要：目的研究糙苏叶中的化学成分。方法采用柱层析对糙苏叶中的提取物进行分离提纯,并利用现代波谱方法分析鉴定,确定化合物的结构。结果分离并鉴定出10个环烯醚萜类化合物,它们分别为:(1S*,3R*,4S*,5S*,6R*,7R*,8S*,9S*)-3,8-epoxy-1-hydroxy-4-methoxycarbonyl-10-methyl-6,7-acetonide-cis-2-oxabicyclo[4.3.0]nonane(1),(1R*,3R*,4S*,5S*,6R*,7R*,8S*,9S*)-3,8-epoxy-1-hydroxy-4-methoxycarbonyl-10-methyl-6,7-acetonide-cis-2-oxabicyclo[4.3.0]nonane(2),8-acetylshanzhigenin methyl ester(3),8-acetyl-1-epishanzhigenin methyl ester(4),shanzhigenin methyl ester(5),1-epishanzhigenin methyl ester(6),1β-hydroxy-dihydrocornin aglycone(7),1α-hydroxy-dihydrocornin aglycone(8),独一味素A(9),独一味素B(10)。结论从糙苏叶中分离得到的10个化合物中,化合物1、2、7和8为首次从该属植物中分离得到。Objective To study the chemical constituents of Phlomis umbrosa. Methods The compounds of iridoid were isolated by means of silica gel column chromatography and elucidated by spectroscopic experiments. Results Ten iridoid compounds isolated from the air-dried and powdered leaves of Phlomis umbrosa Turcz. All these compounds were as follows：（ 1S^＊,3R^＊,4S^＊,5S^＊,6R^＊,7R^＊,8S^＊,9S^＊）-3,8-epoxy-1-hydroxy-4-methoxycarbon-yl-10-methyl-6,7-acetonide-cis-2-oxabicyclo[4. 3. 0] nonane（ 1）;（ 1R^＊,3R^＊,4S^＊,5S^＊,6R^＊,7R^＊,8S^＊,9S^＊）-3,8-epoxy-1-hydroxy-4-methoxycarbonyl-10-methyl-6,7-acetonide-cis-2-ox-abicyclo[4. 3. 0]nonane（ 2）; 8-acetylshanzhigenin methyl ester（ 3）; 8-acetyl-1-epishanzhig-enin methyl ester（ 4）; shanzhigenin methyl ester（ 5）; 1-epishanzhigenin methyl ester（ 6）; 1β-hydroxy-dihydrocornin aglycone（ 7）; 1α-hydroxy-dihydrocornin aglycone（ 8）; lamiophlomiol A（ 9）; lamiophlomiol B（ 10）. Conclusion Compounds 1,2,7 and 8 were all first isolated from the genus.

关 键 词：糙苏 化学成分 环烯醚萜 提取分离 

分 类 号：R284.2[医药卫生—中药学]