红细胞参数偏高者捐献单采血小板安全性的初步观察研究  

Effects of plateletpheresis on the routine red blood cell indexes in donors with higher than average red blood cell parameters

作　　者：林绮文[1] 陈锦艳[1] 张婷[1] 朱晓梅[1] 刘诗[1] 黄建华[1] 

机构地区：[1]广州血液中心,广东广州510095

出　　处：《中国输血杂志》2016年第2期134-136,共3页Chinese Journal of Blood Transfusion

基　　金：广州市医药卫生科技一般引导项目(20141A011064)

摘　　要：目的研究捐献单采血小板对红细胞参数偏高献血者血常规的影响。方法通过专业征询和体格检查的志愿无偿献血者根据血常规结果分成2组:RBC(5.5-6.5)×1012/L和/或Hb含量(160-175)g/L的实验组和一般献血者的对照组。对比捐献单采血小板前后实验组与对照组的血常规参数及单采14 d后2组血常规恢复情况。监测红细胞参数偏高者长期多次单采前后血常规,观察长期多次单采对他们血常规的影响。结果单采前实验组的RBC为(5.95±0.59)×1012/L,Hb含量为(166±10.44)g/L高于对照组的(4.94±0.38)×1012/L和(133.30±13.80)g/L;实验组的MCV为(75.62±5.35)f L低于对照组的(80.72±5.40)f L,差异均具有统计学意义(P<0.05)。但Plt计数,实验组为(272.83±49.95)×109/L,对照组为(267.30±52.81)×109/L,差异没有统计学意义(P>0.05)。其余参数如WBC、HCT、MPV等差异没有统计学意义。单采后实验组RBC为(5.24±0.78)×1012/L和Hb含量为(148±11.79)g/L仍高于对照组的(4.11±0.64)×1012/L和(115.80±17.40)g/L,实验组MCV为(74.87±5.01)f L仍低于对照组的(78.93±5.76)f L,差异有统计学意义。但Plt、WBC等其余参数两组差异没有统计学意义,说明红细胞参数偏高不影响血小板计数和采集。长期多次单采后,红细胞参数偏高献血者血常规各参数保持稳定,可以在短时间内恢复到采前水平。结论捐献单采血小板对红细胞参数偏高者的血常规参数无明显不良影响。Objective To evaluate the effects of plateletpheresis on the blood routine indexes in donors with higher than average red blood cell parameter. Method Donors were divided into two groups according to their red blood cell count and hemoglobin concentration. The blood routine indexes were determined and analyzed before, after and 14 days after plateletph- eresis. The blood routine indexes in frequent donors with higher than average red blood cell parameter were monitored. Re- suits Before, after or 14 days after plateletpheresis, there were no significant difference in the blood routine indexes be- tween the donors with higher than average red blood cell parameter and the control group, such as PLT, MPV, WBC, etc. Higher red blood cell parameter had no impact on plateletpheresis. The blood routine indexes in donors with higher than aver- age red blood cell parameter remained stable after frequent plateletpheresis. Conclusion Plateletpheresis had no impact on the blood routine indexes in donors with higher than average red blood cell parameters.

关 键 词：红细胞 单采血小板 安全性 

分 类 号：R331.141[医药卫生—人体生理学] R193.3[医药卫生—基础医学]