新诊断2型糖尿病患者血清前蛋白转化酶枯草溶菌素9水平的变化及其临床意义  

Serum PCSK9 level and its clinical value in patients with newly diagnosed type 2 diabetes

作　　者：郭雯[1] 欣冰[2] 杨涛[1] 李杰[2] 陈晓倩[2] 王亚梅[2] 上官海燕[2] 仲彬[2] 周红文[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,210029 [2]南京市市级机关医院内分泌科

出　　处：《中国糖尿病杂志》2016年第4期296-300,共5页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81170747);江苏省六大人才高峰(2008-18D)

摘　　要：目的探讨前蛋白转化酶枯草溶菌素9(PCSK9)在新诊断T2DM患者及NGT人群中的差异及其与血糖、胰岛素及其他代谢指标的关系。方法选取新诊断T2DM患者200例和NGT者244名,ELISA检测血清PCSK9水平。结果 T2DM组血清PCSK9水平高于NGT组[(90.58±40.48)vs(63.09±33.83)ng/ml](P<0.01)。总人群血清PCSK9水平与年龄、SBP、BMI、WC、TC、TG、LDL-C、FPG、FIns、胰岛素抵抗指数(HOMA-IR)呈正相关,与HDL-C呈负相关(P<0.05);NGT组血清PCSK9水平与年龄、TC、LDL-C、FIns、HOMA-IR呈正相关(P<0.05);T2DM组血清PCSK9水平与TC、TG、LDL-C、FPG、FIns、HOMA-IR呈正相关(P<0.05)。多元逐步回归分析显示,LDL-C是PCSK9的影响因素,总人群及T2DM患者中,FPG是PCSK9的影响因素。结论 T2DM患者血清PCSK9水平高于NGT人群.PCSK9可能参与了糖尿病的发生发展。Objective To investigatethe difference of proprotein convertase subtilisin/ kexin type 9（PCSK9） level between patients with newly diagnosed type 2 diabetes mellitus（T2DM） and people with normal glucose tolerance（NGT）,and evaluate the correlation between serum PCSK9 and glucose,insulin and other metabolic factors.Methods A total of 200 T2 DM patients and 244 NGT subjects were randomly enrolled in this study.Serum PCSK9 level was measured by EL1 SA.Results Serum PCSK9 level was higher in T2 DM group than in NGT group[（90.58 ± 40.48） vs（63.09 ±33.83）ng/ml]（P0.01）.Serum PCSK9 level was positively correlated with age,SBP,BMI,WC,TC,TG,LDL-C,FPG,Fins and HOMA-IR and negatively correlated with HDL-C（P〈0.05）.Serum PCSK9 level was positively correlated with age,TC,LDL-C,FIns and HOMATR in NGT group（P〈0.05） and positively correlated with TC,TG,LDL-C,FPG,FIns and HOMA-IR in T2 DM group（P〈0.05）.Multiple stepwise regression analysis showed that LDL-C was an influencing factor for PCSK9 and FPG was an influencing factor for PCSK9 in the whole study population and T2 DM group.Conclusion Serum PCSK9 level is higher in T2 DM patients than in NGT subjects.PCSK9 may play a role in the development of T2 DM.

关 键 词：前蛋白转化酶枯草溶菌素9 糖尿病 2型 低密度脂蛋白胆固醇 

分 类 号：R587.1[医药卫生—内分泌]