糖代谢异常患者血清脂肪细胞脂肪酸结合蛋白的变化及其临床意义  

Serum adipocyte-fatty acid binding protein level and its clinical value in patients with abnormal glucose tolerance

作　　者：杨华[1] 杨晓东[1] 饶丽华[1] 刘云涛[2] 

机构地区：[1]三峡大学仁和医院检验科,宜昌443001 [2]三峡大学仁和医院内分泌科,宜昌443001

出　　处：《中国糖尿病杂志》2016年第4期309-312,共4页Chinese Journal of Diabetes

摘　　要：目的观察不同血糖水平血清脂肪细胞脂肪酸结合蛋白(A-FABP)水平,探讨其与IR的相关性。方法选取NGT组55名、IGT组53例及T2DM组56例,测定各组血清A-FABP、FPG、2 hPG、TC、TG、FIns等指标,计算BMI,WHR及胰岛素抵抗指数(HOMA-IR),分析A-FABP与IR的相关性。结果 T2DM组血清A-FABP水平高于IGT组和NGT组[(71.14±10.03)vs(36.69±8.01)vs(19.49±2.98)mg/L,P<0.05]。相关分析显示,血清A-FABP水平与BMI、WHR、TC、TG、HDL-C、LDL-C、HbA_1c、2 hPG、高敏C反应蛋白(hsC-RP)、HOMA-IR相关(r=0.739、0.320、0.202、0.213、0.695、0.248、0.842、0.441、0.354、0.695,P<0.05或P<0.01)。多元回归逐步分析显示,BMI、WHR、HbA_1c、HOMA-IR是影响血清A-FABP的独立危险因素(t=2.621、4.461、7.362、3.875,P<0.05)。结论 A-FABP与IR关系密切,随着IR程度的加重,A-FABP水平逐渐升高。Objective To observe serum adipocyte-fatty fatty acid binding protein（A-FABP） level and its association with insulin resistance in patients with different glucose tolerance.Methods A total of 164 patients were enrolled in this study and divided into three groups：normal glucose tolerance（NGT group,n=55）,impaired glucose tolerance（IGT group,n=53） and type 2 diabetes mellitus（T2DM group,n=56）.A-FABP,FPG,2 hPG,TC,TG,FIns were tested in all subjects.BMI,WHR and HOMA-IR were calculated and the relationship between A-FABP and IR was analyzed.Results A-FABP level was higher in T2 DM group than in IGT and NGT group[（71.14±10.03）vs（36.69 ± 8.01）vs（19.49 ± 2.98）mg/L,P〈0.05].Association analysis showed that serum A-FABP was positively correlated with BMI、WHR,TG,TC,LDL-C,HbA_1c,2 hPG,hsC-RP and HOMA-IR（r=0.739,0.320,0.202,0.213,0.248,0.842,0.441,0.354,0.695,P〈0.05 or P〈0.01）,but was negatively correlated with HDL-C（r =-0.695,P 0.01）.Multiple regression analysis showed that BMI,WHR,HbA_1c HOMA-IR were independent influencing factors for A-FABP（t= 2.621,4.461,7.362,3.875,P〈0.05）.Conclusion A-FABP is closely related to IR.The level of A-FABP rises with the increase of IR severity.

关 键 词：脂肪细胞脂肪酸结合蛋白 胰岛素抵抗 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]