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作 者:陈静[1] 周翔海[1] 庞梦端 田金莉[2] 许林鑫[3] 高学营 刘艳[1] 段妍[1] 刘越素[4] 纪立农[1]
机构地区:[1]北京大学人民医院内分泌代谢科,100044 [2]唐山市工人医院内分泌二科 [3]山西医科大学第一医院内分泌科 [4]山西医科大学第二医院内分泌科
出 处:《中国糖尿病杂志》2016年第4期321-324,共4页Chinese Journal of Diabetes
摘 要:目的探讨影响住院T2DM患者左心室舒张功能不全(LVDD)的相关因素。方法连续收集1013例住院T2DM患者的临床资料,采用超声心动图检测左心室舒张功能。Logistic回归分析LVDD的影响因素。结果 51.3%的患者存在LVDD。LVDD组较非LVDD组年龄[(49.0±12.1)vs(61.3±10.0)岁]、中位糖尿病病程(7.0 vs 11.0年)、WC[(93.6±11.0)vs(95.4±10.7)cm]、SBP[(128±16)vs(134±18)mmHg]、Cr[(61.4±15.7)vs(68.0±30.0)μmol/L]、尿白蛋白/肌酐(UAlb/Cr)(4.3vs6.2 mg/g)升高(P〈0.05);Logistic回归分析显示,年龄、WC、SBP、LDL-C、Cr与LVDD独立相关[OR(95%CI):1.110(1.091-1.129)、1.023(1.007-1.039)、1.013(1.004-1.022)、1.264(1.052-1.519)、1.010(1.001-1.020),P〈0.05];在无高血压史患者中,随HbA1 c增高,LVDD患病风险增高,但差异无统计学意义(P=0.055)。结论住院T2DM患者中,LVDD患病率高,年龄、WC、SBP、LDL-C和Cr增高与LVDD独立相关。Objective To investigate risk factors for left ventricular diastolic dysfunction(LVDD)in type 2 diabetic patients admitted to hospital.Methods Clinical data of 1013 patients with type 2diabetes admitted to hospital were collected consecutively.Echocardiography was used to measure LVDD.Logistic regression analysis was used to identify associated factors for LVDD.Results 51.3%of the patients had LVDD.Age[(49.0 ± 12.1) vs(61.3±10.0) years].duration of diabetes(med ian duration 7vs 11 years),WC[(93.6 ± 11.0) vs(95.4 ± 10.7) cm],systolic blood pressure(SBP)[(128 ± 16) vs(134±18) mmHg],serum creatinine(Cr)[(61.4 ± 15.7) vs(68.0+30.0) μmol/L],and urinary albuminto creatinine ratio(UACR)(6.2 to 4.3 mg/g) were higher in patients with LVDD than in patients without LVDD(P〈0.05).Logistic regression analysis showed that age,WC,SBP,LDL-C and Cr[QR(95%CI):1.110(1.091-1.129),1.023(1.007-1.039),1.013(1.004-1.022),1.264(1.052-1.519),1.010(1.001 - 1.020);P 0.05]were independent risk factors for LVDD.In patients without hypertension,there was a borderline significant association between HbA1c and the presence of LVDD(P= 0.055).Conclusion There is a high prevalence of LVDD in type 2 diabetic patients admitted to hospital.Age,WC,SBP,LDL-C and Cr are independently associated with LVDD.
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