替米沙坦联合瑞舒伐他汀对2型糖尿病合并冠心病患者肝细胞生长因子和过氧化物酶体增殖物激活受体γ的影响  

The effect of Telmisartan and Rosuvastatin on hepatocyte growth factor and peroxisome proliferator activated receptor y in T2DM patients with coronary heart disease

作　　者：刘慧[1] 李海剑[2] 高传玉[3] 李玉东[1] 毛绍芬[1] 陶雅非[2] 任东升[2] 

机构地区：[1]南阳市中心医院特需科,473009 [2]南阳市中心医院肾内科,473009 [3]河南省人民医院心内科

出　　处：《中国糖尿病杂志》2016年第4期335-338,共4页Chinese Journal of Diabetes

摘　　要：目的探讨替米沙坦联合瑞舒伐他汀对T2DM合并冠心病患者血清肝细胞生长因子(HGF)及其受体(c-met)和PPAR-γ表达水平的影响。方法选取95例T2DM合并冠心病患者,将其分为对照组、替米沙坦组和替米沙坦联合瑞舒伐他汀组。检测各组血清HGF、c-met和PPAR-γ水平。结果与对照组比较,替米沙坦组、替米沙坦联合瑞舒伐他汀组治疗后HGF[(338.96±36.51)vs(241.56±29.88)vs(173.23±32.25)pg/ml]、c-met[(0.657±0.162)vs(0.489+0.093)vs(0.247±0.075)ng/m1]和PPAR-γ[(53.76±11.97)vs(35.12±9.66)vs(23.91±6.87)pg/ml]水平降低(P<0.05),且替米沙坦联合瑞舒伐他汀组上述指标较替米沙坦组下降更明显(P<0.05)。结论替米沙坦与他汀类药物联合应用可能改善T2DM合并冠心病患者血管的内皮损伤,为临床防治糖尿病早期冠状动脉粥样硬化提供了新的思路。Objective To investigate the effect of Telmisartan and Rosuvastatin on hepatocyte growth factor（HGF）,HGF receptor[mesenchymal-epithelial transition factor（c-met）]and peroxisome proliferator activated receptor y（PPAR-y） in T2 DM patients with coronary heart disease.Methods A total of 95 T2 DM patients with coronary heart disease were enrolled in this study and divided into three groups：control group,Telmisartan treatment group,and Telmisartan and Rosuvastatin treatment group.Serum HGF,c-met,PPAR-γ were measured in all the patients.Results The levels of HGF,c-met,and PPAR-γ expression were significantly lower in Telmisartan treatment group and Telmisartan and Rosuvastatin treatment group than in control group,HGF[（241.56 ± 29.88） vs（173.23 ± 32.25） vs（338.96±36.51） pg/ml,P〈0.05],c-met[（0.489±0.093）vs（0.247± 0.075）vs（0.657±0.162）ng/ml,P〈0.05]and PPAR-y[（35.12 ±9.66） vs（23.91 ± 6.87） vs（53.76±11.97） pg/ml,P 0.05]respectively.HGF,c-met and PPAR-y were lowest in Telmisartan and Rosuvastatin treatment group（P〈0.05）.Conclusion Telmisartan combined with Rosuvastatin probably has a synergistic effect on prevention and treatment of diabetic vascular endothelial injury.This may be a new way in prevention of coronary atherosclerosis in T2 DM patients.

关 键 词：肝细胞生长因子 糖尿病 2型 冠心病 替米沙坦 瑞舒伐他汀 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]