基于可调谐二极管激光吸收光谱技术的密闭玻璃容器中水汽浓度及压力的探测  

Concentration and pressure measurement of water vapor in sealed glass containers based on tunable diode laser absorption spectroscopy

作　　者：曹亚南[1,2] 王贵师 谈图 汪磊 梅教旭 蔡廷栋[3] 高晓明[1] 

机构地区：[1]中国科学院安徽光学精密机械研究所大气物理化学研究室,合肥230031 [2]中国科学技术大学,合肥230031 [3]江苏师范大学物理与电子工程学院,徐州221116

出　　处：《物理学报》2016年第8期130-135,共6页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:41205120;11104237;61475068)资助的课题~~

摘　　要：冻干法处理过的药品瓶中残存的水汽(H_2O)是药品变质的主要影响因素之一,如何快速准确地测量瓶中的水汽浓度及压力,是检测药瓶是否泄漏的关键.本文报道了利用1.39μm半导体激光器作为光源,结合波长调制吸收光谱技术,实现了对密闭玻璃容器(药瓶)中水汽浓度及压力的探测,并通过转台模拟生产线对系统在动态条件下的性能进行了测试.研究结果表明,在0.2%—12%的H_2O浓度范围内真实值与测量值之间的相关度和标准偏差为0.9978和4.81%,在0.1—100 atm(1 atm=1.01325×105Pa)的压力范围内两者之间的相关度和标准偏差为0.982和5.6%,系统对应的压力及浓度的最低检测限约为2.5 Torr(1 Torr=1.33×102Pa)和400 ppm.通过利用转台以及Labview编写的快速在线处理软件进行了动态条件下的测试,一分钟可以处理300个左右的药瓶,可以很好地满足快速实时探测的要求.该方案可以直接应用于药瓶在线检测,并且使用2台激光器可以实现多组分同时探测分析(如H_2O、氧气等).Water vapor in a sealed glass container processed by lyophilization is a main factor for drug metamorphism. The key to knowing whether there is a leakage occurring in the container is how to detect water concentration and pressure in the sealed container quickly and accurately. In the present paper, a strong absorption line of H2O near 1.39 μm is carefully selected to avoid the interference of neighboring transitions. A distributed feedback laser semiconductor laser near 1.396 μm is employed as the light source with a power of 10 m W and typical linewidth of 2 MHz by combining with tunable diode laser absorption spectroscopy technique, the concentrations and pressures of water vapor in the sealed container are successfully detected under static condition and dynamic condition. In order to isolate the interference absorption from the ambient water vapor in the air, a differential absorption technique is employed in our experiment,which makes our system simpler than routine nitrogen purging based system. During the measurement, the second harmonic signal is utilized for measuring the concentration and pressure, the concentration is retrieved by the peak value while the pressure is calculated by the full width at half maximum. For the measurement of concentration ranging from0.2% to 12%, the linear correlation coefficient between the real values and the inversed values and the standard deviation ratio are 0.9978 and 4.81%, respectively. For the measurement of pressure, the correlation coefficient and standard deviation ratio are 0.982 and 5.6%, respectively. The minimum detection limits of the concentration and pressure are400 ppm and 2.5 Torr, respectively. Moreover, in order to test the system for on-line applications in the pharmaceutical industry, measurements are performed in vials which are placed on a rotary stage to simulate the process of the assemble line. In particular, the amplitude of sinuous signal without absorption is used as the reference signal to validate whether the vial is in the optical path.

关 键 词：可调谐半导体吸收光谱技术 密闭玻璃容器 浓度 压力 

分 类 号：TQ460.7[化学工程—制药化工]