高压氧治疗对重型颅脑损伤合并肺部感染患者降钙素原和C反应蛋白的影响  

Effects of hyperbaric oxygen on procalcitonin and C-reactive protein in patients with severe craniocerebral injury complicated with pulmonary infection

作　　者：袁春儿 吴坚敏[2] 王伟群[2] 陈捷[2] 

机构地区：[1]余姚市第二人民医院检验科,浙江省余姚315400 [2]余姚市人民医院检验科

出　　处：《中华航海医学与高气压医学杂志》2016年第1期6-8,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的观察高压氧（hyperbaric oxygen，HBO）治疗对重型颅脑损伤合并肺部感染患者血清降钙素原（PCT）和c反应蛋白（CRP）水平的影响。方法选取确诊为重型颅脑损伤合并肺部感染并进行HBO治疗的患者60例作为观察组，未进行HBO治疗的重型颅脑损伤合并肺部感染的患者50例作为对照组。HBO疗程为2周，治疗前2组患者间临床肺部感染评分（CPIS）、PCT和CRP水平差异无统计学意义（P〉0．05），观察2组患者治疗后的临床疗效和各实验室指标变化。结果HBO治疗1个疗程后，观察组CPIS（6．86±0．55）较对照组（7．14±0．55）显著下降，差异有统计学意义（P〈0．01）；观察组血清PCT、CRP水平[（0．35±0．15）μg／L，（10．5±1．6）mg／L]较对照组[（0．62±0．18）μg/L，（18．3±5．8）mg／L]明显下降，差异有统计学意义（P〈0．05或P〈0．01）。结论HBO治疗对重型颅脑损伤合并肺部感染患者炎症状态有一定的抑制作用，可作为重型颅脑损伤合并肺部感染患者有效的治疗手段。Objective To observe the effects of hyperbaric oxygen （HBO） on the level of serum procalcitonin （PCT） and C-reactive protein （CRP） in patients with severe eranioeerebral injury complicated with pulmonary infection. Methods Sixty confirmed cases of severe craniocerebral injury complicated with puhnonary infection treated with HBO were selected as the observation group, while another 50 identical cases without HBO treatment were chosen as the control group. The patients received 2 course of HBO. Between treatment, there was no statistical significance in the clinical pulmonary infection scores （CPIS）, serum procalcitonin （PCT） and C-reactive protein （CRP） for the patients of the 2 groups. Following treatment, changes in clinical efficacy and various laboratory indicators were closely observed for the two groups. Results After a course of HBO therapy, CPIS of the observation group （6.86 ± 0.55 ）were significantly lower than that （7.14 ±0. 55 ）of the control group, with statistical significance （P 〈 0.01 ）. The levels of serum PCT and CRP of the observation group [ （0.35 ±0. 15 ）p.g/L, （10.5 ± 1.6）mg/L] were significantly lower than those [ （0.62 ±0.18） μg/L, （ 18. 3 ±5. 8）mg/L] of the control group, also with statistical significance （P 〈0.05 or P 〈 0. 01 ）. Conclusions HBO could produce certain protective effects on the patients with severe craniocerebral injury complicated with pulmonary infection, therefore it could be used as an effective method in the treatment of the patients with severe craniocerebral injury complicated with pulmonary infection.

关 键 词：高压氧 重型颅脑损伤合并肺部感染 血清降钙素原 C反应蛋白 

分 类 号：R651.15[医药卫生—外科学] R563.1[医药卫生—临床医学] R446.1