联合应用MRDCE-TIC与^1H-MRS对乳腺肿瘤的诊断价值  

Diagnostic Value of DCE-MRITime Intensity Curve and Magnetic Resonance Spectroscopy in Breast Tumors

作　　者：祁永红[1] 唐桂波[2] 杨国财[2] 

机构地区：[1]青海大学医学院,青海西宁810001 [2]青海省人民医院,青海西宁810007

出　　处：《青海师范大学学报（自然科学版）》2016年第1期81-86,共6页Journal of Qinghai Normal University(Natural Science Edition)

摘　　要：目的探讨单独应用MR动态增强扫描（DCE）时间-信号强度曲线（TIC）、氢质子磁共振波谱（^1H-MRS）与二者联合应用对乳腺肿瘤的诊断价值.方法回顾性分析41例乳腺肿块（恶性肿瘤23例,良性肿瘤18例）的DCE-TIC和^1H-MRS表现,并与手术或穿刺后病理结果对比.所有患者均为女性,年龄17-69岁,平均（41.0±14.7）岁,均应用GE公司的1.5TSigna HDxt扫描仪,8通道乳腺专用线圈,扫描序列包括：轴位STIR、TIWI、乳腺容积动态增强序列（VIBRANT）和1 H-MRS扫描,评价单独应用DCE-MRI时间-信号强度曲线（TIC）、磁共振波谱（^1H-MRS）及二者联合应用对诊断乳腺肿瘤的诊断能力.结果 ①以DCE-TIC类型诊断乳腺肿瘤的敏感度为82.6%,特异度为77.8%,准确度为80.5%;②以^1H-MRS出现Cho峰诊断乳腺肿瘤的敏感度为70.0%,特异度为83.3%,准确度为75.6%;③将TIC与1 H-MRS Cho峰结合,诊断的敏感度为78.0%,特异度为88.9%,准确率为82.9%.结论 DCE-MRI TIC诊断乳腺肿瘤的特异度较低,联合应用DCE-TIC和^1H-MRS可提高乳腺肿瘤性病变的诊断特异度、准确度.Objective：To investigate the value of combined dynamic contrast-enhanced breast magnetic resonance scan（DCE-MRI）time-intensity curves with ^1H magnetic resonance spectroscopy（MRS）in the diagnosis of breast tumors.Methods：Retrospectively analyzed the DCE-TIC and ^1H-MRS findings of 41 cases with breast tumors,including 23 malignant cases and 18 benign cases,and compared with the pathological results after surgery or biopsy.All patients are women,17 to 69-year-old,average 41-yearold,All scanning was performed on a 1.5T GE Signa HDxt scanner,an eight-channel bilateral breast radiofrequency coil was used,scanning sequence includes short time inversion recovery（STIR）、TIWI、VIBRANT in the axial orientation and 1 H magnetic resonance spectroscopy（MRS）.DCE-MRI TIC and 1 HMRS of all lesions were jointly analyzed in the identification of benign and malignant breast tumors.Results：The diagnostic sensitivity,specificity and accuracy rate of TIC alone was 82.6%,77.8%and80.5% respectively.Magnetic resonance spectroscopy（MRS）of diagnosis sensitivity of breast cancer is70.0%,specificity is 83.3%,accuracy is 75.6%.The diagnostic sensitivity,specificity and accuracy rate for combined application of TIC and MRS was 78.0%,88.9% and 82.9%respectively.Condusion：The specificity of DCE-TIC in the diagrosis of breast tumors is low,and the combined application of DCE-TIC and′H-MRS can improve the diagrostic spectficty and accuracy of breast tumors.

关 键 词：乳腺肿块 磁共振 动态增强 时间信号强度曲线 氢质子波谱 

分 类 号：R816.4[医药卫生—放射医学]