盐酸氨溴索注射液与猪肺磷脂注射液治疗新生儿肺透明膜病的疗效比较  

Comparison on Efficacy of Ambroxol Hydrochloride Injection Combined with Poractant Alfa Injection in Treatment of Neonatal Hyaline Membrane Disease

作　　者：李振国[1] 胡芳[1] 王素芳[1] 

机构地区：[1]湖北省监利县人民医院新生儿科,湖北荆州433300

出　　处：《中国医院用药评价与分析》2016年第3期331-333,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:观察新生儿肺透明膜病应用盐酸氨溴索注射液与猪肺磷脂注射液治疗的临床效果。方法:选取湖北省监利县人民医院2014年1月—2015年1月收治的100例新生儿肺透明膜病,按随机数字表法分为观察组和对照组,每组各50例。观察组患儿采用盐酸氨溴索注射液联合新型鼻塞持续气道正压通气(nasal continuous positive airway pressure,NCPAP)治疗,对照组患儿采用猪肺磷脂注射液联合NCPAP治疗,对2组患儿临床治疗效果进行观察和比较。结果:观察组患儿治疗有效率78.00%(39/50),低于对照组患儿治疗有效率80.00%(40/50),差异无统计学意义(P>0.05);2组患儿治疗前、后动脉血二氧化碳分压(PaCO_2)、血氧分压(PaO_2)差异显著,治疗后6、12 h组间PaCO_2、PaO_2比较,差异有统计学意义(P<0.05),治疗24 h组间比较,差异无统计学意义(P>0.05);2组患儿吸氧时间、症状改善时间、住院时间比较,差异无统计学意义(P>0.05)。结论:针对新生儿肺透明膜病,盐酸氨溴索注射液与猪肺磷脂注射液分别联合NCPAP治疗效果相当,均能实现不错的临床效果,猪肺磷脂注射液起效相对较快,而盐酸氨溴索注射液药物价格低廉,临床应根据患儿实际情况制定合理的治疗方案,以此获取令人满意的治疗效果。OBJECTIVE： To observe and analyze the clinical effects of ambroxol hydrochloride injection combined with poractant alfa injection in treatment of neonatal hyaline membrane disease（ HMD）. METHODS： 100 cases of HMD admitted into Hubei Jianli County People＇s Hospital from Jan. 2014 to Jan. 2015 were selected to be divided into observation group and control group via the random number table,with 50 cases in each. The observation group were treated with ambroxol hydrochloride injection combined with nasal continuous positive airway pressure（ NCPAP）,while the control group received poractant alfa injection combined with NCPAP,the clinical treatment effects were compared and observed between two group of patients. RESULTS： The total effective rate of observation group was 78. 00%（ 39 /50）,lower than that of control group80. 00%（ 40 /50）,the difference was not statistically significant（ P〉0. 05）. The PaCO2,PaO2 of two group of patients before and after treatment had significant difference. After treatment,the PaO2 and PaCO2 were significantly different between 6 and12 h groups（ P〈0. 05）; and there was no significant difference in 24 h group（ P〉0. 05）. Meanwhile,there was no statistically significant difference of oxygen time,improvement time of symptoms and length of stay between two group of patients（ P〉0. 05）. CONCLUSIONS： The treatment effects of ambroxol hydrochloride injection and poractant alfa injection respectively combined with NCPAP in treatment of neonatal hyaline membrane disease are equivalent,both of which could achieve significant clinical efficacy. And the effects of poractant alfa injection is relatively fast,while the price of ambroxol hydrochloride injection is low. The clinic are suppose to formulate the rational treatment regimen according to the practical situation,so as to obtain satisfactory results.

关 键 词：新生儿 肺透明膜病 猪肺磷脂注射液 盐酸氨溴索注射液 

分 类 号：R974[医药卫生—药品]