合并糖尿病的颈内动脉重度狭窄侧支循环情况分析  

Analysis of the Collateral Circulation of Severe Stenosis of Internal Carotid Artery in the Patients with Diabetes Mellitus

作　　者：刘涵瑜 钟池[2] 张萌[1] 王洪海[2] 许晓伟[2] 胡鸣一[2] 牟小华[2] 

机构地区：[1]潍坊医学院神经病学教研室,山东潍坊261053 [2]潍坊市人民医院神经内科

出　　处：《潍坊医学院学报》2016年第2期126-128,共3页Acta Academiae Medicinae Weifang

摘　　要：目的分析比较糖尿病组与非糖尿病组颈内动脉重度狭窄或闭塞后侧支循环情况与缺血事件的随访观察。方法取自2014年1月~2014年12月在我院经颈部血管彩超（DUS）确认的单侧颈内动脉重度狭窄（≥70%）或闭塞的患者77例,设立糖尿病组（37例）和非糖尿病组（40例）,行颅多普勒超声（TCD）判断颅内侧支循环,比较分析两组侧支开放数目。结果卡方检验分析两组侧支循环开放数目,非糖尿病组2个侧支开放率高于糖尿病组（P〈0.05）;侧支开放种类两组比较无显著差异（P〉0.05）;随访1年发现非糖尿病组中5例发生TIA,糖尿病组12例,差异有统计学意义（P〈0.05）。结论糖尿病可能阻碍狭窄后颅内侧支循环开放,侧支血管的发生受损在糖尿病患者中风的发病机制中可能是另一个重要因素。Objective To compare the number of patent collateral detected by transcranial Doppler ultrasonography（ TCD） between DM group and non-DM group and ischemic events observed by one-year follow-up. Methods Seventy-seven patients were studied with severe degree of DUS proven unilateral stenosis of internal carotid artery（ ≥70%） or occlusion registered in weifang people＇s hospital from January 2014 to December 2014. The studied subjects were divided into DM group（ n = 37） and non-DM group（ n = 40）. The number of detected collaterals vessels and ischemic events between two groups were compared. Results Applying the chi square test to analysis the collateral pathways in two groups,more collateral branches were found in non-DM group than DM group（ P〈0. 05）. Subjects with diabetes mellitus had a higher likelihood to suffer ischemic events（ P〈0. 05）. Conclusion Diabetes mellitus hindered the development of intracranial collateral vessels in patients with carotid occlusive disease. Our results suggest that impaired development of collateral arteries may be another imporant factor of stroke pathogenesis in diabetic patients.

关 键 词：糖尿病 颈内动脉狭窄 脑血管造影 侧支循环 

分 类 号：R543.4[医药卫生—心血管疾病]