雌激素对雌性大鼠脂质代谢及血糖影响的研究  

Effects of estrogen on lipid metabolism and glucose of female rats

作　　者：奚玲[1] 李璐[1] 张日华[1] 黄琼[1] 刘梦兰[1] 刘云[1] 

机构地区：[1]南京医科大学第一附属医院老年医学科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2016年第2期189-192,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81070684);江苏省卫生厅兴卫工程重点个人项目(RC2011069);南京医科大学第一附属医院创新团队(20113012)

摘　　要：目的 :探讨雌激素对SD大鼠脂质代谢及血糖的影响。方法 :将40只7周龄的雌性SD大鼠随机分为4组:1对照组(Con组);2假手术组(sham组);3去卵巢组(OVX组);4去卵巢+雌激素替代组(OVX+E2组)。术后定期记录体重,给予相应处理,20周龄时测量空腹血糖并进行糖耐量试验,心脏穿刺取血,检测血浆总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),同时取腹部脂肪称重。结果:与对照组相比,OVX组大鼠体重明显增加,腹部脂肪重量增加,血浆中TC、TG和LDL-C含量明显增加,空腹血糖无异常改变,但存在一定程度的糖耐量异常。OVX+E2组使用剂量雌激素替代治疗后,与对照组相比,体重明显减轻,腹部脂肪重量减轻,血脂无异常改变。结论:雌激素水平与体重呈负相关,雌激素水平下降可引起大鼠脂质代谢异常及胰岛素抵抗,补充雌激素后上述异常得到改善。Objective：To investigate the effect of estrogen on lipid metabolism and glucose. Methods：Fotry 7-week-old female Sprague-Dawley rats were randomly divided into 4 groups,the control group（Con）,sham-operated group（sham）,ovariectomy（OVX）group and OVX rats given high dose E2treatment（OVX ＋ E2）. After being weighted,each group of rats were given corresponding processing. Nine weeks later,the change of visceral fat weight,total cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL）,high-density lipoprotein（HDL） and glucose were measured. Results：Compared with the control group,the body weight and abdominal fat of OVX group increased significantly. There was a significant difference in the level of TG,TC and LDL between the control and OVX groups. But in the high dose E2-treated OVX group it showed no significant differences. Compared with sham operation group rats,fasting blood glucose was of no difference in OVX group,but existed impairing glucose tolerance. Conclusion：The estrogen level was negatively correlated with the body weight,lower estrogen induced abnormal lipid metabolism and insulin resistance. But this phenomenon can be reversed after treated with estrogen.

关 键 词：雌激素 雌激素替代治疗 脂质代谢 糖耐量异常 

分 类 号：R589.2[医药卫生—内分泌]