Dactylospongia属海绵的化学成分及生物活性研究进展  

Advances in studies on chemical constituents in marine sponges of genus Dactylospongia and their bioactivities

作　　者：王洁[1] 焦伟华[2] 黄健[1] 王金辉[1] 林厚文[1,2] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]上海交通大学医学院附属仁济医院海洋药物重点实验室,上海200127

出　　处：《中国海洋药物》2016年第2期103-110,共8页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目(41106127;81422054;81202441;81172978)资助

摘　　要：Dactylospongia属海绵中已报道的次生代谢产物主要包括倍半萜醌和倍半萜氢醌类、倍半萜衍生物、大环内酯及甾醇等结构类型,大多具有良好的生物活性,包括抗肿瘤、抗炎及抗菌等。本文根据化合物的结构类型综述了1989-2014年之间经文献报道的Dactylospongia属海绵的化学成分和生物活性,为该属海绵的进一步研究开发提供了参考。Sponges of the genus Dactylospongia mainly comprise sesquiterpene quinones,sesquiterpene hydroquinones,sesquiterpene derivatives,macrolides,sterols and other types of chemical components,many of them show various and potent biological activities,including antitumor,immunoregulatory and antimicrobial activities.This review summarized the chemical constituents and bioactivities of the reported sponges of the genus Dactylospongiafrom 1989 to 2014,which provides reference for further research of the genus Dactylospongiasponges.

关 键 词：Dactylospongia属海绵 化学成分 倍半萜醌类 生物活性 

分 类 号：R931[医药卫生—生药学]