乌梅肉提取物抗腹泻作用研究  

Experimental Study on Anti-diarrheal Activity of Pulp of Mume Fructus Extraction

作　　者：王小婷[1] 蒋国政[1] 王海滨[1] 王凤霞[1] 李艳华[1] 盛尊来[1] 

机构地区：[1]东北农业大学动物医学学院,哈尔滨150030

出　　处：《中国现代应用药学》2016年第4期407-410,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：黑龙江省教育厅科学技术研究项目(12531047)

摘　　要：目的研究乌梅提取物抗腹泻作用,为临床应用提供依据。方法通过蓖麻油致小鼠腹泻模型、小肠炭墨推进实验、大鼠肠腔积液实验,以腹泻抑制率、小肠推进率、肠腔积液体积为指标,研究乌梅提取物的抗腹泻作用。结果乌梅水提物及水提醇沉提取物均具有抗腹泻作用,其中水提醇沉提取物的活性明显高于水提物(P<0.05),显著抑制正常小鼠的小肠推进运动(P<0.05或0.01),但对肠腔积液作用不显著。结论乌梅提取物具有一定的抗腹泻作用,其抗腹泻机制可能与抑制小肠运动有关。OBJECTIVE To study the anti-diarrheal activity of Pulp of Mume Fructus extraction. METHODS Anti-diarrheal activity of Mume Fructus extraction was evaluated using castor oil-induced diarrhea, charcoal meal transit and castor oil-induced enteropooling in different group mice or rats. RESULTS Mume Fructus extraction and its preliminary purified extraction both possessed anti-diarrheal property in mice and the latter was superior to the former. Although the preliminary purified extraction did not decreased the volume of castor oil-induced intestinal fluid secretion, it caused a dose-dependent decrease of gastrointestinal transit（P〈0.05）. CONCLUSION The findings of this study indicate that Mume Fructus extraction possesses anti-diarrhoeal property that related with decreasing gastrointestinal transit.

关 键 词：腹泻 乌梅 腹泻抑制率 小肠推进率 肠腔积液 

分 类 号：R285.5[医药卫生—中药学]