5-HT能神经通路参与偏头痛的机制研究进展  

Research Progress of the Mechanism of 5-HT Neural Pathway on Migraine

作　　者：裴培[1] 刘璐[1] 赵洛鹏 曲正阳[1] 唐楚英 王麟鹏[1] 

机构地区：[1]首都医科大学附属北京中医医院针灸中心,北京100010

出　　处：《中国现代应用药学》2016年第4期497-501,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：国家重点基础研究发展计划(973计划;2014CB543203);北京市医院管理局重点医学专业发展计划项目(ZYLX201412);北京市自然科学基金项目(7154205)

摘　　要：偏头痛是一种常见的复杂性神经系统疾病。研究证实,下行抑制/易化系统的5-HT能神经通路通过分布在三叉神经血管痛觉通路各级结构上不同亚型的5-HT受体,介导了下行抑制/易化系统中抑制和易化疼痛的双重调痛作用,与偏头痛病理生理机制的形成及治疗密切相关。本文拟对与偏头痛相关的5-HT受体亚型进行综述,以期为临床治疗偏头痛提供新思路。Migraine is a common and complex brain disorder. Studies found that 5-HT neurons arising from descending inhibition and/or facilitation systems involved in the pathophysiology and treatment of migraine by activating different 5-HT receptor subtypes located at trigeminal neurovascular pain pathways, which mediated the dual role, facilitating and/or inhibiting pain. In this review, we briefly describe the different 5-HT receptors associated with migraine, attempt to provide new insights into the clinical prevention and treatment of migraine.

关 键 词：偏头痛 下行抑制/易化系统 5-HT 5-HT受体 

分 类 号：R96[医药卫生—药理学]