慢性乙型肝炎患者血清铁蛋白检测在判断肝脏受损中的临床应用  

Clinical Significance of Serum Ferritin Level in the Determination of Liver Damage in Patients with Chronic Hepatitis B

作　　者：邓测川 李立新[1] 唐江涛[1] 陶传敏[1] 罗俐梅[1] 严可宁[1] 王兰兰[1] 

机构地区：[1]四川大学华西医院实验医学科,成都610041

出　　处：《华西医学》2016年第4期692-696,共5页West China Medical Journal

摘　　要：目的探讨慢性乙型肝炎(乙肝)患者血清铁蛋白(SF)含量与肝脏受损之间的关系。方法 2014年7月-10月检测98例慢性乙肝患者的SF,检测血清乙肝病毒(HBV)DNA载量(HBV-DNA),统计分析不同HBVDNA载量组间SF水平的差异,并将SF与甲胎蛋白及肝功能指标谷丙转氨酶(ALT)、谷草转氨酶(AST)、总蛋白、白蛋白、总胆红素、乙肝血清标志物乙肝表面抗原、乙肝表面抗体、乙肝e抗原、乙肝e抗体、乙肝核心抗体进行相关性分析。结果 98例慢性乙肝患者SF升高异常率为53.06%、SF升高者的SF浓度为(878.69±837.98)ng/m L;HBV-DNA低载量与高载量两组间SF均数比较差异有统计学意义(P<0.05);SF与ALT、AST、总胆红素呈正相关(P值均<0.01),与总蛋白、白蛋白呈负相关(P值均<0.01)。结论慢性乙肝患者的SF升高程度与肝损伤密切相关,可反映机体的炎症状态。Objective To explore the relationship between the level of serum ferritin（SF） and liver damage in patients with chronic hepatitis B（CHB）.Methods The concentration of serum ferritin of 98 patients with CHB from July to October 2014 was measured,and then correlation analysis was performed to analyze the correlation between SF and such indexes as serum tumor marker α-fetoprotein,biochemical markers [alanine amino transferase（ALT）,aspartate amino transferase（AST）,total protein（TP）,albumin and total bilirubin（TBIL）],and hepatitis B serum markers（hepatitis B surface antigen,hepatitis B surface antibody,hepatitis B e antigen,hepatitis B e antibody,and hepatitis B core antigen）.Serum hepatitis B virus DNA（HBV-DNA） viral load was also tested,and then the discrepancy of SF levels in the high and low viral load groups was analyzed.Results The average concentration of the abnormally elevated SF was（878.69±837.98） ng/m L.The SF mean difference between low-load HBV-DNA and high-load HBV-DNA was statistically significant（P〈 0.05）.Serum ferritin levels were independently and positively correlated with ALT,AST,and TBIL（P〈 0.01） and inversely correlated with TP and albumin（P〈 0.01）.Conclusion The rise of SF is associated with liver damage,which can rel ect the state of inl ammation of patients with CHB.

关 键 词：慢性乙型肝炎 血清铁蛋白 肝损伤 

分 类 号：R512.62[医药卫生—内科学]