中国大陆首例输入性寨卡病毒感染病例临床表现及实验室检测结果分析  

Clinical manifestations and laboratory test results of the first imported Zika virus infection in China's Mainland

作　　者：李建华[1] 黄仁发[1] 杨健平[1] 熊衍峰[1] 罗鸿华 胡国良[3] 刘晓青[3] 廖勇[1] 

机构地区：[1]赣州市疾病预防控制中心,江西341000 [2]赣县疾病预防控制中心 [3]江西省疾病预防控制中心

出　　处：《中国公共卫生》2016年第4期413-415,共3页Chinese Journal of Public Health

摘　　要：目的分析中国大陆首例输入性寨卡病毒感染病例的临床表现及实验室检测结果,为寨卡病毒病的预防控制提供参考依据。方法通过对病例进行流行病学个案调查,收集相关病历资料,并开展相关实验室检测,应用描述性流行病学方法对病例的临床表现及实验室检测结果进行分析。结果病例男性,34岁于2016年2月2日从委内瑞拉出发,途经中国香港、广东省深圳和东莞,于2月5日抵达江西省赣州市赣县,2月6日被收入赣县人民医院感染性疾病科接受隔离治疗,2月14日痊愈出院;病例临床表现为发热、头晕头痛、畏寒、乏力、皮疹、眼眶痛、结膜充血、腹泻等症状;病例白细胞和血小板值正常,单核细胞比率略有升高,凝血酶原时间略有升高,肝肾功能检查白蛋白、尿素氮、尿酸略有下降,左下肺轻度肺气肿改变;病原学检测结果显示,病例尿液标本寨卡病毒核酸存在时间较血清标本长,发病第15 d病例唾液标本未检出核酸阳性。结论本例病例为一典型但症状较轻的输入性寨卡病毒感染病例,对具有流行病学史且同时出现发热或皮疹等症状的归国人员进行排查,采集其血清、尿液等多种标本进行检测,有利于病例的早期发现、诊断和治疗。Objective To analyze clinical manifestations and laboratory test results of the first imported Zika virus infection in M ainland China and to provide references for preventing Zika virus infection. Methods Epidemiological investigation and laboratory tests were conducted and relevant medical records were collected. Descriptive epidemiology method was adopted to analyze the clinical manifestations and laboratory test results. Results A 34 years old male local citizen was hospitalized on February 6,2016 in Infectious Disease Department of Ganxian County People＇ s Hospital for the treatment and isolation of Zika virus infection diagnosed based on positive result of Zika virus nucleic acid and negative results of chikungunya and dengue virus nucleic acid by real-time reverse transcription-polymerase chain reaction（ RT-PCR） at the hospital admission. The patient arrived in Ganxian county of Jiangxi province on February 5,2016,travelling from Venezuela on February 2,2016,via Hong Kong,Shenzhen and Dongguan of Guangdong province,China. The patient reported the history of mosquito bite and visiting a doctor due to fever on January 28,2016 while staying in Venezuela. The patient was cured and discharged in February 14,2016. The clinical manifestations of the patient were fever,dizziness,headache,chills,fatigue,skin rash,orbital pain,conjunctival hyperemia,and diarrhea. The counts of white blood cell and platelet were normal. M onocyte ratio and prothrombin time increased slightly,while the contents of albumin,blood urea nitrogen,uric acid decreased slightly. A mild emphysema change was observed in the left lung. The duration for Zika virus positive for urine samples of the patient was longer than that for serum samples. The nucleic acid of Zika virus in saliva samples was negative at the 15 th days after the onset of the disease. Conclusion The reported case was an imported Zika virus infection with mild but typical clinical symptoms. Screening with urine and blood sample detections should be conducted among returni

关 键 词：寨卡病毒 输入性 首例 中国大陆 临床表现 实验室检测 

分 类 号：R181.32[医药卫生—流行病学]