深圳市百日咳流行特征及1~15岁人群抗体水平调查  

Prevalence of pertussis and serum Bordetella pertussis antibody level among 1-15 years old children in Shenzhen city,2009-2013

作　　者：樊静洁[1] 

机构地区：[1]深圳市妇幼保健院预防保健科,广东518028

出　　处：《中国公共卫生》2016年第4期453-455,共3页Chinese Journal of Public Health

摘　　要：目的了解深圳市百日咳流行特征和疫情发生影响因素,检测1~15岁人群百日咳血清抗体水平,评价免疫效果并为免疫程序提供科学依据。方法通过国家疾病监测信息报告管理系统收集深圳市2009—2013年百日咳病例资料,分析深圳市百日咳流行特征,用ELISA检测方法检测1~15岁人群百日咳血清抗体水平,采用病例对照研究方法分析百日咳影响因素。结果深圳市2009—2013年共报告百日咳163例,年平均发病率为0.32/10万,发病高峰在7—8月,发病人群主要集中在5月龄以内,占全部发病85.27%;监测256人,百日咳抗体阳性率为38.30%,不同年龄百日咳抗体水平差异无统计学意义（χ2=4.737,P〉0.05）。接触史、住房面积和家庭收入是影响发病的主要因素。结论深圳百日咳以婴幼儿发病为主;不同年龄组百日咳血清抗体保护率呈上升趋势;接触是百日咳发病的重要危险因素。Objective To investigate prevalent characteristics and influencing factors of pertussis and to evaluate serum Bordetella pertussis antibody level among children in Shenzhen city for providing evidence for assessing immunization efficiency and scheduel. Methods Data on pertussis cases reported between 2009- 2013 in Shenzhen city were extracted from Natinal Disease Surveillance Information for pertussis prevalence analysis. Enzym-linked immunosorbent assay（ ELISA） was used to detect surum Bordetella pertussis antibody level among community children aged 1- 15 years selected with stratified random cluster sampling. Totally 23 reported petussis cases and 69 age-and residence-matched controls were surveyed with a questionnaire to analyze factors associated with petussis incidence. Results There were 163 cases of pertussis cases reported and the average annual incidence was 0. 32 /100 000 in Shenzhen city during the period.M ore petussis cases were reported between July to August in a year and 85. 27% of all reported cases were small children aged under 5 months. Among 256 community children receiving serum antibody test,the Bordetella pertussis positive rate was 38. 30% and no significant difference in the positive rate was observed among the children of various age groups（ χ2= 4. 737,P〉 0. 05）. The major infullencing factors for pertussis incidence included history of contact with cough sufferer,residential housing area and familial income. Conclusion Pertussis incidents occurred mainly among infants,with contacting with cough sufferer as a major risk factors,and serum Bordetella pertussis antibody level increased in children of various ages in Shenzhen city between 2009 and 2013.

关 键 词：百日咳 流行病学特征 抗体水平 

分 类 号：R516.6[医药卫生—内科学]