甲醛对果蝇寿命及其在应激条件下耐受性的影响  

The Effects of Formaldehyde on Life Span and Stress Resistance in Drosophila melanogaster

作　　者：李一凝[1,2] 赫荣乔[1] 

机构地区：[1]脑与认知科学国家重点实验室,中国科学院生物物理研究所,北京100101 [2]中国科学院大学,北京100049

出　　处：《生物化学与生物物理进展》2016年第4期420-428,共9页Progress In Biochemistry and Biophysics

基　　金：国家重点基础研究发展计划(973)资助项目(2012CB911004)~~

摘　　要：虽然甲醛对人及动物多种器官的毒性作用已经有了大量研究,但不同浓度甲醛影响动物寿命的研究还极其少见.本文用黑腹果蝇作为模式生物,在食物中添加不同浓度的甲醛,观察果蝇寿命及其在应激条件下耐受性的变化.实验结果显示,雌性果蝇的寿命表现出对甲醛浓度的依赖,0.037%甲醛可以极显著地延长雌性果蝇的寿命,较高浓度甲醛(≥0.185%)可以极显著地缩短雌性果蝇与雄性果蝇的寿命.0.037%甲醛还可以极显著地增强雌性和雄性果蝇对饥饿以及高温的耐受性,但减弱其对活性氧的耐受性.这些结果有助于从新的途径研究果蝇寿命及其在应激条件下耐受性的分子机制.There were lots of studies reporting the toxic effects of formaldehyde on various organs of human and animals, but the differences of effects among various concentrations of formaldehyde were rarely reported. In this paper, we used Drosophila melanogaster as model organism, added different proportions of formaldehyde into the fly food, and observed the effects on life span and stress resistance. The results showed that the life span of female flies depended on the formaldehyde concentrations, 0.037% formaldehyde could significantly extend the life span of female flies, whereas the higher concentrations of formaldehyde（≥0.185%） could significantly reduce the life span of male and female flies. What＇s more, 0.037% formaldehyde significantly increased the starvation resistance and heat shock resistance, but reduced the oxidative resistance in both male and female flies. These results provided a new way to study the molecular mechanisms of longevity and stress resistance in Drosophila.

关 键 词：甲醛 果蝇 寿命 饥饿耐受性 高温耐受性 活性氧耐受性 

分 类 号：Q4[生物学—生理学] Q5