斑点追踪成像技术联合组织多普勒评价降脂消斑片改善冠心病患者心功能的临床研究  

Evaluation of Jiangzhi Xiaoban Tablet in Improving Heart Function of Coronary Heart Disease Patients by Doppler Tissue Imaging and Speckle Tracking Imaging Technology

作　　者：王月爱[1] 余习蛟[1] 程丑夫[2] 阳力[2] 刘芳[1] 周梦红[1] 谭云[2] 

机构地区：[1]湖南中医药大学第一附属医院超声科,长沙410007 [2]湖南中医药大学第一附属医院中医内科,长沙410007

出　　处：《中国中西医结合杂志》2016年第4期399-402,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：湖南省中医药管理局基金项目(No.2014137);湖南省科技厅基金项目(No.2014SK3162)

摘　　要：目的采用斑点追踪成像技术联合组织多普勒评价降脂消斑片改善冠心病患者心功能的作用。方法 60例均为2013年10月—2014年11月湖南中医药大学第一附属医院就诊住院的经冠状动脉造影已确诊为冠心病的患者。按随机数字表法分为治疗组(A组)30例和对照组(B组)30例。A组服用降脂消斑片(0.45g/片),4片/次,3次/天,口服;B组采用辛伐他汀片(20mg/片),1片/次,每晚1次,口服。两组疗程均为8周。两组治疗前后均采用斑点追踪成像技术联合组织多普勒进行心脏长轴切面18节段STI的纵向峰值应变LS和TDI收缩期峰值Sa参数测定。结果治疗前两组各节段STI的纵向峰值应变LS和TDI收缩期峰值Sa比较,差异均无统计学意义(P>0.05);两组治疗后各节段STI的纵向峰值应变LS和TDI收缩期峰值Sa均较治疗前增高(P<0.05);治疗后B组各节段STI参数LS及TDI各节段参数Sa均明显低于治疗后A组(P<0.01)。结论降脂消斑片能不同程度的改善冠心病心功能,疗效优于西医常规(辛伐他汀片)治疗。Objective To evaluate the role of Jiangzhi Xiaoban Tablet（JXT）in improving heart function of coronary heart disease（CHD）patients by tissue Doppler imaging（TDI）and speckle tracking imaging（STI）technology.Methods Recruited were 60 inpatients with confirmed CHD by coronary angiography at First Affiliated Hospital,Hunan University of Traditional Chinese Medicine from October 2013 to November 2014.They were assigned to the treatment group（group A）and the control group（group B）according to random digit table,30 cases in each group.Patients in group A took JXT,0.45 g/tablet,4tablets each time,3times per day,while those in group B took Simvastatin Tablet,20 mg/tablet,1 tablet each time,once per evening.The therapeutic course for all was 8 weeks.The long axis view of the heart of 18 segments STI Peak strain LS and TDI peak systolic Sa parameters were performed in all patients before and after treatment.Results Before treatment segments of STI strain LS and TDI longitudinal peak systolic peak Sa were not statistically different between the two groups（P〉0.05）.Each segment of STI peak longitudinal strain LS and TDI peak systolic Sa in the two groups were higher after treatment than before treatment（P〈0.05）.After treatment each segment of STI parameters of LS and each TDI segment parameters of Sa were significantly lower in group B than in group A（P〈0.01）.ConclusionJXT could improve heart function of CHD patients to different degrees,and its curative effect was better than that of routine Western medicine（Simvastatin Tablets）treatment.

关 键 词：降脂消斑片 斑点追踪成像技术 组织多普勒 心功能 

分 类 号：R259[医药卫生—中西医结合]