当代名老中医治疗冠心病用药规律的聚类分析  

Cluster Analysis of Medication Laws for Treating Coronary Heart Disease by Distinguished Veteran Doctors of Traditional Chinese Medicine

作　　者：任毅[1] 陈志强[2] 张敏州[3] 郭力恒[3] 何德英[1] 

机构地区：[1]重庆市中医院心内科,重庆400021 [2]广东省中山市中医院介入科,广东528400 [3]广东省中医院胸痛中心,广州510120

出　　处：《中国中西医结合杂志》2016年第4期411-414,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：重庆市科学技术委员会资助项目(No.CSTC2015JCSF10001-05);广东省中医院名医工作室资助项目(No.201416)

摘　　要：目的基于数据挖掘技术,对当代名老中医治疗冠心病病案方药进行频数分析和聚类分析,为临床冠心病治疗组方用药提供启发和思路。方法以中国万方医学网、维普医药信息资源系统、中国知网和《当代名老中医典型医案集》中的386则医案为数据源,按照统一标准处理后录入数据库,采用频数分析和聚类分析等方法分析当代名老中医治疗冠心病用药规律。结果丹参、川芎、栝蒌、半夏、当归、茯苓、黄芪、人参、薤白和麦冬是名老中医治疗冠心病使用频率最高的前10味药;聚类分析总结出名老中医常用药对16个,3味药物组合体7个,多味药物组合体5个。结论当代名老中医治疗冠心病多以健脾化痰、行气活血等药物组合为主,同时兼顾运用养心安神、调补阴阳等药物组合。Objective To provide inspiration and ideas for clinical treatment of coronary heart disease（CHD）by data mining technology based frequency analysis and cluster analysis of medical records,prescriptions and herbs in treating CHD by distinguished veteran doctors of traditional Chinese medicine（TCM）.Methods Totally386 medical cases were retrieved from Wanfang Data,Chinese Scientific Journals Database（VIP medical information resources system）,China National Knowledge Infrastructure（CNKI）,and Typical Collections of Medical Cases by Contemporary Distinguished Veteran Doctors of Traditional Chinese Medicine.They input into database trimmed after unified standard.Medication laws of CHD by distinguished veteran doctors of TCM were analyzed using frequency analysis and cluster analysis,and so on.Results Distinguished veteran doctors of TCM frequently used top ten herbs in treatment of CHD as Salvia miltiorrhiza,Ligusticum wallichii,Trichosanthes kirilowii,Pinellia ternate,Angelica sinensis,Poria cocos,Astragalus,Panax ginseng,Allium macrostemon,and Radix Ophiopogonis.Cluster analysis summarized that there were 16 herb pairs commonly used,7drug assemblies consisting of 3 herbs,and 5 drug assemblies consisting of multiple herbs.Conclusions Distinguished veteran doctors of TCM mainly used herbs assemblies capable for invigorating Pi to resolve phlegm,and promoting qi and activating blood circulation in treating CHD.Meanwhile,they concurrently used herbs combination of nourishing Xin and tranquilization,and regulating yin and yang.

关 键 词：冠心病 名老中医 用药规律 聚类分析 

分 类 号：R259[医药卫生—中西医结合]