连云港农村地区男性高血压人群中饮酒与血脂的相关性分析  

The relationship of alcohol drinking with serum lipid levels in Lianyungang rural male adults with hypertension

作　　者：於涛[1] 王雯[1] 王力炜[1] 杨文彬[1] 王滨燕[2] 唐根富[1] 臧桐华[1] 秦献辉[2] 王玉[2] 李建平[3] 霍勇[3] 徐希平[1] 

机构地区：[1]安徽医科大学生物医学研究所,安徽合肥230032 [2]南方医科大学南方医院国家肾脏病临床医学研究中心,广东广州510515 [3]北京大学第一医院心内科,北京100034

出　　处：《中华疾病控制杂志》2016年第4期370-373,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81473052);“十二五”国家重大新药创制专项(2012ZX09101105)

摘　　要：目的探讨连云港农村地区男性高血压人群中饮酒状态与血脂的关系及其影响因素。方法 2008年5月在连云港农村地区进行流行病学调查,通过问卷调查收集受试者的饮酒状况和其他相关变量,实验室检测血清总胆固醇(total cholesterol,TCHO)、甘油三酯(triglyceride,TG)、高密度脂蛋白(high density lipoprotein,HDL-C),由Friedewald公式计算低密度脂蛋白(low density lipoprotein,LDL-C),采用多元线性回归评估饮酒与血脂指标的关联。结果 5 574名男性受试者纳入分析。调整年龄、体质指数、血压、血糖、吸烟、体力劳动强度后,与不饮酒者相比,现在饮酒者的总胆固醇(β=15.58,sx-=1.30,P<0.001)、高密度脂蛋白(β=8.01,sx-=0.43,P<0.001)、低密度脂蛋白(β=7.71,sx-=1.17,P<0.001)水平差异有统计学意义,甘油三酯(β=-0.71,sx-=1.88,P=0.704)组间差异无统计学意义。在糖尿病人群中,饮酒与总胆固醇(与非糖尿病人群比较,交互作用P<0.001)、低密度脂蛋白(与非糖尿病人群比较,交互作用P=0.001)升高具有更强的关联。结论现在饮酒与总胆固醇、高密度脂蛋白、低密度脂蛋白水平呈显著正相关,与甘油三酯差异无统计学意义。Objective To investigate the association between alcohol drinking and blood lipid levels as well as the influencing factors in Lianyungang rural male adults with hypertension. Methods An epidemiological investigation was conducted in May 2008 in rural areas of Lianyungang. Baseline data collection, including alcohol drinking status, was con- ducted by trained research staff using a standardized questionnaire designed specifically for the study. Serum total cholester- ol（TCHO） , triglyceride （TG） and high-density lipoprotein cholesterol （HDL-C） were measured using automatic clinical analyzers （Beckman Coulter）. Low-density lipoprotein cholesterol （LDL-C） was estimated by the Friedewald formula. Mul- tivariate linear regression models were applied to evaluate the relation between alcohol drinking status and blood lipid lev- els. Results A total of 5 574 male participants were included in the final analysis. After adjustment for age, body mass in- dex, blood pressure, fasting glucose, smoking and physical activity levels, compared to never alcohol drinkers, current al- cohol drinkers showed significantly increased concentrations of serum TCHO （ β = 15.58, sx = 1. 30, P 〈 0. 001 ） , HDL-C （β=8.01,sx =0.43, P〈0.001）and LDL-C（β =7.71,sx =1.17,P〈0.001）, but had no significant effect on the TG levels （ β = -0. 71 , sx = 1. 88, P =0. 704）. Furthermore, a greater association between alcohol assumption and the in- crease of TCHO （versus participants without diabetes, P for interaction 〈 0. 001 ） or LDL-C （versus participanls withuut diabetes, P for interaction =0. 001 ） levels was observed in participants with diabetes. Conclusions Alcohol drinking was significantly associated with increased total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cho- lesterol levels. There was no significant association between alcohol drinking and the level of triglyeeride.

关 键 词：饮酒 血脂异常 高血压 

分 类 号：R544.1[医药卫生—心血管疾病] R181[医药卫生—内科学]