非洛地平并阿托伐他汀对单纯收缩期高血压的疗效  

Therapeutic effect of felodipine combined atorvastatin on isolated systolic hypertension

作　　者：吴芳[1] 羿凤云 刘祖德[1] 程志英[1] 

机构地区：[1]中国人民武装警察部队总医院药剂科,北京市100039 [2]中国人民武装警察部队北京总队第三医院药械科

出　　处：《心血管康复医学杂志》2016年第2期188-191,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的：探讨非洛地平联合阿托伐他汀对老年单纯收缩期高血压（ISH）的临床疗效。方法：选择2012年3月-2014年1月在我院就诊的老年ISH患者176例,随机均分为非洛地平组（仅接受非洛地平和其他常规治疗）和联合治疗组（在非洛地平组的基础上加用阿托伐他汀）,两组疗程均为12周。测量比较两组患者治疗前后收缩压（SBP）、舒张压（DBP）、脉压（PP）、肱动脉内皮依赖性舒张功能（FMD）、一氧化氮（NO）、高敏C反应蛋白（hsCRP）和白介素-6（IL-6）水平。结果：与治疗前比较,两组治疗后SBP、PP、hsCRP和IL-6水平均显著降低,FMD和NO水平显著升高（P均〈0.01）。与非洛地平组比较,治疗后联合治疗组SBP[（134.64±9.64）mmHg比（130.86±9.75）mmHg],PP[（68.57±6.01）mmHg比（57.84±5.79）mmHg],hsCRP[（11.94±2.95）mg/L比（7.47±1.97）mg/L]和IL-6[（10.64±3.85）mg/L比（5.84±3.11）mg/L]水平降低更显著,DBP[（72.64±7.95）mmHg比（77.94±8.13）mmHg],FMD[（9.75±2.56）%比（12.54±4.65）%]和NO[（53.74±8.65）μmol/L比（86.48±6.84）μmol/L]水平升高更显著,P〈0.05或〈0.01。结论：非洛地平联合阿托伐他汀对老年单纯收缩期高血压的临床疗效好,有利于血管功能的恢复,降低炎症反应。Objective：To explore therapeutic effect of felodipine combined atorvastatin on aged patients with isolated systolic hypertension（ISH）.Methods：A total of 176 aged ISH patients were selected from our hospital from Mar2012 to Jan 2014.They were randomly and equally divided into felodipine group（only received felodipine and other routine therapy）and combined treatment group（received atorvastatin based on treatment of felodipine group）,both groups were treated for 12 weeks.Levels of systolic blood pressure（SBP）,diastolic blood pressure（DBP）,pulse pressure（PP）,fore brachial artery endothelium dependent diastolic-systolic function（FMD）,nitric oxide（NO）,high sensitive C reactive protein（hsCRP）and interleukin（IL）-6 were measured and compared between two groups before and after treatment.Results：Compared with before treatment,after treatment there were significant reductions in levels of SBP,PP,hsCRP and IL-6,and significant rise in FMD and NO level in both groups（P〈0.01all）.Compared with felodipine group after treatment,there were significant reductions in levels of SBP [（134.64±9.64）mmHg vs.（130.86±9.75）mmHg],PP [（68.57±6.01）mmHg vs.（57.84±5.79）mmHg],hsCRP[（11.94±2.95）mg/L vs.（7.47±1.97）mg/L]and IL-6[（10.64±3.85）mg/L vs.（5.84±3.11）mg/L],and significant rise in DBP [（72.64±7.95）mmHg比（77.94±8.13）mmHg]and FMD [（9.75±2.56）% vs.（12.54±4.65）%]and NO [（53.74±8.65）μmol/L vs.（86.48±6.84）μmol/L]in combined treatment group,P〈0.05or0.01.Conclusion：Felodipine combined atorvastatin possesses good therapeutic effect in aged patients with isolated systolic hypertension.It＇s help to recovering vascular function and lower inflammatory reactions.

关 键 词：高血压 非洛地平 阿托伐他汀 

分 类 号：R544.1[医药卫生—心血管疾病]