心外膜脂肪组织与冠状动脉粥样硬化性心脏病关系及其机制的研究进展  

Progress in epicardial adipose tissue and coronary atherosclerosis heart disease

作　　者：杜俣 吉庆伟[1] 王志坚[1] 赵迎新[1] 

机构地区：[1]首都医科大学附属北京安贞医院心内科12病房,北京市心肺血管疾病研究所,北京100029

出　　处：《临床心血管病杂志》2016年第4期324-327,共4页Journal of Clinical Cardiology

基　　金：国家自然科学基金项目(No:81170625);北京市保健科研课题(No:京13-12)

摘　　要：目前认为,内脏脂肪组织堆积是冠状动脉粥样硬化性心脏病重要的危险因素。心外膜脂肪组织是内脏脂肪的一种类型,除了发挥代谢、产热和机械作用,还能分泌多种脂肪因子直接作用于邻近的冠状动脉,进而影响冠状动脉粥样硬化性心脏病进程。本文从解剖学、生理学、病理学、病理生理学和循证医学角度对心外膜脂肪组织与冠状动脉粥样硬化性心脏病关系及其机制的研究进展做一综述。Currently,the accumulation of visceral adipose tissue has been considered as the important risk factor for coronary atherosclerotic heart disease.Epicardial adipose tissue,a type of visceral adipose tissue exerting metabolic,thermogenic and mechanical functions,participates in the development of coronary atherosclerotic heart disease owing to its secreted adipokines has direct impact on adjacent coronary vasculature.This review mainly focuses on the association and its mechanism between epicardial adipose tissue and coronary atherosclerotic heart disease from the aspects of anatomy,physiology,pathology,physiopathology and evidence based medicine.

关 键 词：心外膜脂肪组织 冠状动脉粥样硬化性心脏病 脂肪因子 

分 类 号：R541.4[医药卫生—心血管疾病]