肾去交感神经术防治心血管疾病的基础研究进展  

Research progression of renal denervation on animal models for cardiovascular diseases

作　　者：徐三彬[1] 郑建普[1] 刘宗军[1] 

机构地区：[1]上海市普陀区中心医院上海中医药大学附属普陀医院心内科,上海200062

出　　处：《临床心血管病杂志》2016年第4期408-413,共6页Journal of Clinical Cardiology

基　　金：上海市卫生和计划生育委员会重点项目(No:20134003);上海市医学重点学科(No:ZK2015A17);上海中医药大学中医学一流学科建设项目(No:ZYD201302)

摘　　要：交感神经系统异常激活是高血压、慢性心力衰竭、心律失常等心血管疾病的共同病理机制。肾去交感神经术(renal denervation,RDN)可通过选择性阻断肾交感神经而降低全身和肌肉交感神经活性,研究表明其对众多心血管疾病有较好的治疗效果。本文旨在综述RDN影响心血管疾病发生发展的最新进展,为其临床应用提供理论依据。The augmented sympathetic activity plays an important role in the development and progression of cardiovascular diseases including hypertension,chronic heart failure,arrhythmia,metabolic syndrome and chronic kidney diease.It has been demonstrated that renal denervation（RDN）by selectively ablating renal sympathetic nerves decreases systemic sympathetic activity,and hence exhibits protective effects on resistant hypertension,heart failure,arrhythmia,etc.The purpose of this review is to provide insight into the effects of RDN on animal models for cardiovascular diseases and the underlying mechanisms.

关 键 词：肾去交感神经术 高血压 心力衰竭 心律失常 代谢综合征 

分 类 号：R544.1[医药卫生—心血管疾病]