芪白平肺颗粒中人参和黄芪提取工艺的优化  

Optimization of the extraction processes of Panax ginseng and Astragalus membranaceus in Qibai Pingfei Granules

作　　者：靳瑞婷 陶永华[3,2,4] 李雪峰[3,2,4] 吴云[3,2,4] 王振中[3,2,4] 萧伟[3,2,4] 

机构地区：[1]南京中医药大学,江苏南京210000 [2]中药制药过程新技术国家重点实验室,江苏连云港222047 [3]江苏康缘药业股份有限公司,江苏连云港222047 [4]中药提取精致新技术重点研究室,江苏连云港222047

出　　处：《中成药》2016年第4期795-800,共6页Chinese Traditional Patent Medicine

摘　　要：目的优化芪白平肺颗粒中人参和黄芪的提取工艺。方法在单因素试验的基础上,采用Box-Behnken响应面法,以乙醇体积分数、药液比、提取时间为自变量,并通过信息熵法对人参皂苷Rg_1+Re、人参皂苷Rb_1、黄芪甲苷的含有量及干膏率进行客观加权。然后,以综合指标为因变量,优化实验结果。结果最佳提取条件为8倍量70%乙醇,提取2次,每次2 h。结论 Box-Behnken响应面与信息熵的结合可用于优化芪白平肺颗粒的提取工艺。AIM To optimize the exctraction processes of Panax ginseng and Astragalus membranaceus in Qibai Pingfei Granules. METHODS Based on single factor experiment,Box-Behnken response surface method was used with ethanol concentration,solvent ratio and extraction time as independent variables. The contents of ginsenoside Rg1＋ Re,ginsenosides Rb1 and astragaloside A,together with the ratio of dry extraction were objectively weighted by information entropy. Then the test result was optimized with comprehensive index as dependent variable. RESULTS The optimal extraction conditions were 8- fold 70% ethanol and extracting twice（ two hours each time）. CONCLUSION The combination of Box-Behnken response surface and information entropy can be used for optimizing the extraction process of Qibai Pingfei Granules.

关 键 词：芪白平肺颗粒 人参 黄芪 提取工艺 Box-Behnken响应面 信息熵 

分 类 号：R284.2[医药卫生—中药学]