基于毒理学关注阈值方法的邻苯二甲酸二甲酯和邻苯二甲酸二乙酯的风险评估  

Risk assessment of dimethyl 1,2-benzenedicarboxylate and 1,2-benzenedicarboxylic acid diethyl ester with the threshold of toxicological concern approach

作　　者：雍凌 燕燕 刘兆平 张磊 隋海霞 宋雁 

机构地区：[1]国家食品安全风险评估中心,北京100022

出　　处：《中国食品卫生杂志》2016年第2期254-258,共5页Chinese Journal of Food Hygiene

基　　金：国家科技支撑计划(2012BAK01B01)

摘　　要：目的运用毒理学关注阈值(TTC)方法对邻苯二甲酸二甲酯(DMP)和邻苯二甲酸二乙酯(DEP)两种邻苯二甲酸酯类物质进行风险评估。方法利用TTC决策树方法和Toxtree软件对DMP和DEP进行Cramer结构分类;利用2002年中国居民营养与健康状况调查数据和24类主要食物中DMP和DEP的含量数据,估计中国不同年龄组人群DMP和DEP的膳食暴露量,并按照TTC决策树方法对其进行风险评估。结果 DMP和DEP属于Cramer I类结构,其对应的TTC阈值为30μg/kg BW。中国居民的DMP和DEP最大暴露量分别为2.43和1.72μg/kg BW,占TTC阈值的8.10%和5.72%;划分成8个性别年龄组后的最大暴露量分别为2.01和1.44μg/kg BW,占TTC阈值的6.71%和4.79%。结论中国居民膳食DMP和DEP的健康风险较低,不需要引起健康关注。Objective To apply the threshold of toxicological concern（TTC）approach to the risk assessment of dimethyl1,2-benzenedicarboxylate（DMP）and 1,2-benzenedicarboxylic acid diethyl ester（DEP）.Methods Cramer schematic diagram and Toxtree software were used to classify DMP and DEP into Cramer systems.DMP and DEP exposure in general population as well as in different age groups was estimated by using data from the Chinese National Nutrition and Health Survey in 2002 and data of DMP and DEP contents in 24 kinds of foods.TTC decision tree approach was used for risk assessment and the exposure was compared with the corresponding TTC value.Results DMP and DEP belongs to class I Cramer and its TTC value was 30 μg/kg BW.The maximum dietary exposures of general population and four age groups were 2.43 and 1.72 μg/kg BW respectively,which are 8.10% and 5.72% of their TTC value.Among 8 age groups,the maximum dietary exposures of DMP and DEP are 2.01 and 1.44 μg/kg BW.These exposure values accounted for 6.71%and 4.79% of TTC values.Conclusion The dietary exposure of DMP and DEP in Chinese population was low and no health concern was required.

关 键 词：邻苯二甲酸二甲酯 邻苯二甲酸二乙酯 塑化剂 毒理学关注阈值 风险评估 Cramer分类 

分 类 号：R114[医药卫生—卫生毒理学]