高同型半胱氨酸血症对2型糖尿病患者血糖控制的影响  

The Effect of High Homocysteine on Blood Glucose Control in Type 2 Diabetic Patients

作　　者：张梅[1] 胡大春[1] 赵晓丽[1] 张鸿青[1] 

机构地区：[1]昆明市第一人民医院,云南昆明650011

出　　处：《昆明医科大学学报》2016年第4期62-64,共3页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学联合专项基金资助项目(2014FZ056)

摘　　要：目的探讨高同型半胱氨酸血症对2型糖尿病患者血糖控制的影响.方法选择无糖尿病急、慢性并发症,并排除有器质性病变的2型糖尿病患者186例,按同型半胱氨酸(Hcy)水平分为2组,1组(单纯糖尿病)70例;2组(糖尿病伴高Hcy)116例,根据使用药物的作用强度不同,赋予不同的权重并计算降糖综合用药指数,观察两组在FPG、Hb A1c控制相同时,其用药指数的差异.结果 1、2组Hcy分别为(8.33±1.16)μmol/L和(14.53±4.74)μmol/L;综合用药指数分别为:(4.9±2.63)和(7.16±2.16).2组的综合用药指数差异有统计学意义(P<0.05);Hcy水平与综合用药指数呈正相关(r=0.252,P<0.01).结论糖尿病伴高Hcy患者的降糖治疗比单纯糖尿病者的用药更复杂、治疗难度更大.Objective To investigate the effect of high homocysteine on blood glucose control in type 2diabetic patients. Me thod We selected 186 cases of organic disease that without diabetes acute and chronic complications, and ruled out the type 2 diabetic patients with organic disease, these enrolled cases were divided into two groups according to Homocysteine（Hcy） levels, group 1（Simple diabetes） 70 cases and group 2（diabetes with high Hcy） 116 cases. According to the different intensity of the drugs,different weights were given to calculated index of hypoglycemic agents,and then the difference of the drug use index between the two groups at the same Condition of Hb A1 c and FPG was observed.Re s ults In group 1 and group 2,Hcy levels were 8.33 ± 1.16 and 14.53 ± 4.74, respectively;comprehensive treatment indexes were（4.9 ± 2.63） and（7.16 ± 2.16）,respectively. Composite index had a significant difference between the two groups（P〈0.05）; The level of Hcy was positively correlated with the index of Comprehensive drug（r =0.252, P〈0.01）. Conclus ion Glucose lowering therapy for diabetic patients with high Hcy is more complex and difficult than for the simple diabetic patients.

关 键 词：糖尿病 同型半胱氨酸 治疗 

分 类 号：R587.1[医药卫生—内分泌]