针刺联合艾灸治疗类风湿性关节炎及血管新生调控因子的作用研究  

Effect of acupuncture and moxibustion on the expression of vascular endothelial growth factor in RA rat models

作　　者：申博[1] 陈迪[1] 林子昊 徐超[1] 刘竹青[1] 

机构地区：[1]安徽中医药大学针灸骨伤临床学院,安徽合肥230038

出　　处：《山西中医学院学报》2016年第1期25-27,共3页Journal of Shanxi College of Traditional Chinese Medicine

基　　金：2014年安徽中医药大学大学生创新创业项目(2014043)

摘　　要：目的:探讨针刺联合艾灸治疗对类风湿性关节炎(RA)模型鼠趾围及滑膜组织中血管内皮生长因子(VEGF)表达的影响。方法:采取风、寒、湿环境因素与生物因子(弗氏完全佐剂)联合制作RA大鼠模型,测量治疗前后各组大鼠趾围,免疫组织化学检测大鼠关节滑膜组织中VEGF表达情况。结果:造模后大鼠踝部和足趾出现明显的炎症红肿。治疗后,与模型组比较,艾灸组、针刺组、联合治疗组大鼠趾围降低;联合治疗组大鼠足趾趾围较针刺组、艾灸组降低(P<0.01);艾灸组、针刺组、联合治疗组大鼠关节滑膜组织中VEGF表达较模型组显著减少(P<0.01),联合治疗组滑膜中VEGF表达较艾灸组、针刺组减少(P<0.01)。结论:针刺联合艾灸可以通过抑制血管内皮生长新生因子改善大鼠RA病情,且效果优于单纯针刺、艾灸治疗。Objective：To investigate the effect of acupuncture and moxibustion on the expression of vascular endothelial growth factor（VEGF）in the toe of rat model of rheumatoid arthritis（RA）. Methods：Rheumatoid arthritis（RA）rat model was made by using the wind,cold,wet environmental factors and biological factors（Freund＇s complete adjuvant）. Rat toe girth was measured and the rat synovial tissue VEGF expression was detected by immunohistochemical method. Results：Rats ankle and toes appearred obvious inflammatory swelling after model establishment. After treatment,compared with model group,moxibustion group,acupuncture group and combined treatment group rats toe girth were decreased and VEGF expression of rat synovial tissue were decreased significantly（P0.01）. Compared with moxibustion group and acupuncture group,VEGF expression of rat synovial tissue in combined treatment group was decreased（P 0.01）. Conclusion：Acupuncture combined with moxibustion can improve the condition of rheumatoid arthritis in rats by inhibiting the growth of vascular endothelial growth factor,and the effect is superior to that of simple acupuncture and moxibustion.

关 键 词：类风湿性关节炎 针刺 艾灸 血管内皮生长因子 

分 类 号：R285.5[医药卫生—中药学]