组织工程技术修复半月板损伤:从基础到临床的差距  

Tissue engineering technology for repair of meniscus injury:from basic to clinic

作　　者：侯立刚[1] 杨建义[1] 

机构地区：[1]郑州大学附属郑州中心医院骨二科,河南省郑州市450007

出　　处：《中国组织工程研究》2016年第11期1651-1657,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:利用组织工程技术构建有功能的半月板为半月板损伤的修复提供了新思路。目的:分析组织工程半月板修复中常用的种子细胞和支架材料研究进展。方法:应用计算机检索CNKI和Pub Med数据库1996至2015年有关半月板损伤修复和组织工程技术的应用方面的文献。中文关键词"半月板损伤、组织工程半月板、生物材料、干细胞",英文关键词"meniscal repair,Meniscal Injury,tissue engineering,tissue-engineered meniscus,biomaterials,stem cells"。结果与结论:组织工程半月板重建是一种较为可行的修复半月板损伤的方法,间充质干细胞具有多向分化潜能,是半月板组织工程理想的种子细胞。支架材料是半月板组织修复再生中最主要的因素之一,天然半月板支架材料起着重要的作用。半月板组织工程支架材料的选择与研制经历了由单一材料向复合材料研制的快速发展时期,复合材料可以弥补单一材料存在的诸多缺点和不足,为新型材料的研制开辟了新思路。组织工程技术能够形成几何形状的半月板组织,而在远期观察半月板组织的生物性能,尚缺乏足够的时间,有待于从基础到临床获得较为可靠的数据来证明组织工程学修复损伤半月板组织的作用。BACKGROUND： The use of tissue engineering technology to build a functional meniscus is a new idea for repair of meniscus injury.OBJECTIVE： To analyze the research progress of seed cells and scaffold materials in tissue-engineered meniscus repair. METHODS： A computer-based search of CNKI and PubM ed was performed for articles related to tissue-engineered meniscus repair published from 1996 to 2015. The keywords were ＂meniscal repair, meniscal injury, tissue engineering, tissue-engineered meniscus, biomaterials, stem cells＂ in Chinese and English, respectively. RESULTS AND CONCLUSION： Tissue-engineered meniscus reconstruction is a more viable method for repair of meniscus injury. Mesenchymal stem cells are pluripotent cells that are ideal seed cells for tissue-engineered meniscus reconstruction. Scaffolds are one of important factors for meniscus repair, and natural meniscal scaffolds play an important role. Selection and development of scaffold materials for meniscus tissue engineering have experienced a rapid development period from a single material to composite materials. Composite materials make up a lot of shortcomings and deficiencies that a single material has, and open up new ideas for developing new materials. Meniscal tissues with geometric shapes can be constructed using tissue engineering technology. However, the long-term observation of the biological properties of meniscal tissues is necessary, and from basic to clinic, there is still a lack of reliable data to prove the effect of tissue engineering technology in the meniscus repair.

关 键 词：半月板 胫骨 软骨细胞 支架 组织构建 组织工程 半月板 种子细胞 生物材料 

分 类 号：R318[医药卫生—生物医学工程]