网格状钛合金钢板及钢丝网修复胸壁缺损的安全性  

Mesh-like titanium alloy steel plate versus wire mesh in the repair of chest wall defects: a safety study

作　　者：刘涛 张勇 

机构地区：[1]潍坊市第二人民医院胸外一科,山东省潍坊市261041 [2]潍坊市第二人民医院呼吸科,山东省潍坊市261041

出　　处：《中国组织工程研究》2016年第12期1793-1799,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:研究表明,钛金属材料具有机械强度高、物理性能稳定、生物相容性好、耐腐蚀性好等优点,可安全应用于人体。目的:对比网格状钛合金钢板及钢丝网修复胸壁缺损的安全性。方法:纳入18例胸壁缺损患者,其中男11例,女7例,年龄19-65岁,其中9例采用网格状钛合金钢板进行修补,另9例采用钢丝网进行修补。修补后1周,采用目测类比评分评估疼痛情况;随访调查胸廓外形满意率及并发症发生情况。结果与结论:两组患者随访1-7年,随访期间复查X射线片显示胸廓稳定性好,未出现网格状钛合金钢板、钢丝断裂及胸壁软化,呼吸功能恢复好,胸壁凹陷畸形不明显,胸廓外形满意率较高,网格状钛合金钢板组胸廓外形满意率显著高于钢丝网组(P<0.05),并发症发生率显著低于钢丝网组(P<0.05),两组胸壁缺损修复后1周的目测类比评分比较差异无显著性意义(P>0.05)。结果表明,网格状钛合金钢板修复腹壁缺损具有良好的生物相容性及安全性,并可有效保持胸壁的稳定性。BACKGROUND： Titanium materials have high mechanical strength, stable physical properties, good biocompatibility, and excellent corrosion resistance, which can be safely used in humans. OBJECTIVE： To compare the safety of mesh-like titanium alloy steel plate versus wire mesh in the repair of chest wall defects. METHODS： Eighteen patients with chest wall defects, 11 males and 7 females, with an age range of 19-65 years, were enrolled. The 9 of 18 patients were subjected to repair with mesh-like titanium alloy steel plate, and the other 9 patients underwent wire mesh repair. At 1 week after repair, visual analog scale scores were measured in the two groups, and patient＇s satisfaction on the thoracic appearance and incidence of complications were surveyed during the follow-up. RESULTS AND CONCLUSION： All patients were followed up for 1-7 years. During the follow-up, X-ray review displayed good thoracic stability and no fracture of titanium plate and wire mesh. Patients recovered well from respiratory dysfunction, with unapparent chest wall deformity and high satisfaction rate of the thoracic appearance. Moreover, compared with the wire mesh group, the satisfaction rate of the thoracic appearance was significantly higher（P〈0.05）, but the incidence of complications was significantly lower in the titanium plate group（P〈0.05）. At 1 week after repair, the visual analog scale scores had no difference between the two groups（P〉0.05）. These findings indicate that the mesh-like titanium plate has good biocompatibility and safety to effectively maintain the stability of the chest wall.

关 键 词：钛 骨固定钢丝 胸壁 组织工程 生物材料 材料相容性 网格状钛合金钢板 钢丝网 胸壁缺损 并发症 安全性 

分 类 号：R318[医药卫生—生物医学工程]