汉语言自由联想功能磁共振的初步研究  

A primary f MRI study of the chinese language function: a free fluency paradigm

作　　者：王鹏[1] 于红梅[1] 杜飞舟[1] 顾明[1] 汪洋[1] 何次[1] 

机构地区：[1]成都军区总医院医学影像科,成都610083

出　　处：《磁共振成像》2016年第4期282-287,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：中国博士后科学基金(编号:2013M542582);成都军区"十二五"科研面上项目(编号:C12036);成都军区总医院面上项目(编号:2013YGB004)~~

摘　　要：目的设计一种适合汉语言自由联想的脑功能磁共振刺激任务,探索汉语言自由联想脑功能区表现。材料与方法对19名健康汉语志愿者进行任务态自由联想语言功能刺激,同时采集功能性磁共振成像(functional magnetic resonance imaging,f MRI)数据,通过SPM8软件分析获取自由联想任务相关主要脑功能区位置,激活大小及最大激活强度。结果汉语自由联想主效应区位于右颞上回(BA21);左颞枕内侧回、左海马旁回在联想任务中没有激活信号,双侧海马的激活程度较低。结论利用该语言任务能激活正常人自由联想语言功能区;同时血氧水平依赖性功能磁共振成像(blood oxygen level dependent functional magnetic resonance imaging,BOLD-f MRI)可以准确定位激活区,量化激活区大小及最大激活强度,技术稳定可靠,适用于汉语言联想相关脑功能区疾病研究。Objective： To design a stimulus task for Chinese free fluency, and explore the brains language function areas in Chinese people. Materials and Methods： Nineteen healthy Chinese volunteers underwent a BOLD-f MRI scan with a free fluency stimulus task, that was block design. All images were collected and processed by SPM 8, followed by a First- and Second-level analysis. The distribution,sizes（number of voxels）, and peak intensity of activations were shown by Xjview.Results： All participants completed the language task in connection with chinese language functional areas located primarily in the right superior temporal gyrus. In this study, the left fusiform gyrus and left parahippocampal gyrus were not activated, and bilateral hippocampus with low-grade activations. Conclusion： This stimulus task effectively activated brain language areas relating to chinese free fluency. BOLDf MRI located activated areas accurately, and quantified the size and peak intensity of activations. It was stable and reliable with good compliance from patients. This study shows that chinese free fluency.

关 键 词：汉语 功能性磁共振成像 脑 语言功能 自由联想 

分 类 号：R445.2[医药卫生—影像医学与核医学] R338.2[医药卫生—诊断学]