四种倍半萜类化合物广谱抗肿瘤效应的研究进展  

Advances in broad-spectrum antitumor effect of four sesquiterpenoids

作　　者：乔巍[1] 汪小莞[1] 李晓春[1] 李江[2] 李晓萌[1] 

机构地区：[1]东北师范大学生命科学学院,吉林长春130024 [2]吉林大学口腔医院口腔修复科,吉林长春130041

出　　处：《中国生化药物杂志》2016年第3期5-8,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金：科技部国际合作项目(2010DFA31430);吉林省科技厅(20130521010JH;20150101187JC;20150414007GH);吉林省教育厅题(2015-526;2015-551);高校基本科研业务费专项基金(2412015ZH005;130017507);国家自然科学基金(30871301;30700827);引智计划(B07017)

摘　　要：目的倍半萜类化合物(sesquiterpenoids)是存在于自然界中的一大类天然化合物,在植物中最为丰富。小白菊内酯、木香烃内酯、异土木香内酯和土木香内酯是4种具有代表性的倍半萜类化合物,它们主要存在于菊科植物小白菊和土木香等药用植物中,具有镇痛、抗菌及消炎的作用。近年来,这类化合物的抗肿瘤特性引起了科学家的重视。它们对正常的细胞无毒害,却表现了对多种肿瘤细胞的广谱的细胞毒和促凋亡效应,提示了其作为重要肿瘤抑制药物的开发前景。为此,本文就这4种倍半萜类化合物的天然来源、结构特征、分子靶点、抗肿瘤关联信号通路的调节机制等方面作以综述。Sesquiterpenoids are a rich source of natural compounds found in nature,most abundantin plants. Parthenolide,Costunolide,Isoalantolactone and Alantolactone are four representative of sesquiterpenoids,found primarily in the medicinal plants such as compositae including fever few and radix Inulae,which has analgesic, anti-bacterial and anti-inflammatory effects. In recent years,sesquiterpenoids ＇anti-tumor properties attracted the attention of scientists. Especially,sesquiterpenoids have abroadspectrum of cytotoxic effect and promoting apoptosis on various of tumor cells without affecting normal cells,suggesting the development prospects of its important role as an antitumor agents. Therefore,the paper summarized the natural origin,structure,molecular target of the four sesquiterpenoids,as well as their regulating mechanism in antitumor associated signaling pathway.

关 键 词：倍半萜类化合物 癌症 凋亡 信号通路 

分 类 号：R285.5[医药卫生—中药学]