参苓白术散加减方对晚期胃癌化疗患者毒副反应及免疫功能的影响  

Effects of Modified Shenling Baizhu San(参苓白术散) on Immune Function and Toxicity Reaction of Advanced Gastric Cancer Patients in Chemotherapy

作　　者：邵扣凤 肖平[2] 

机构地区：[1]淮安市楚州中医院,江苏淮安223200 [2]南京中医药大学,江苏南京210046

出　　处：《中医药导报》2016年第8期26-28,32,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：江苏高校优势学科建设工程资助项目(YSXK-2010)

摘　　要：目的:探讨参苓白术散加减方对晚期胃癌患者化疗过程中毒性反应及免疫功能的影响。方法:将62例患者随机分为两组各31例,治疗组采用参苓白术散加减方联合FOLFOX4方案治疗,对照组采用FOLFOX4方案化疗。结果:治疗组不良反应显著低于对照组(P<0.05);治疗组体重增加率(64.3%)明显大于对照组(29.2%);治疗组的淋巴细胞转化率、补体C_3、Ig G,Ig A、Ig M提高的例数明显高于对照组;治疗组CD4^+/CD8^+的值高于对照组(P<0.05),IL-6、TNF-α的含量显著低于对照组(P<0.05);对照组和治疗组的中医证候总有效率分别为70.8%和92.9%,两组比较,差异有统计学意义(P<0.05)。结论:参苓白术散加减方能有效降低晚期胃癌化疗患者的毒副反应,提高免疫功能,改善生活质量。Objective： To investigate the effects of Shenling Baizhu San （参苓白术散,SLBZS） on immune function and toxicity in advanced stomach neoplasm. Methods： The sixty-two patients were randomly divided into two groups （treatment group and control group）. Treatment group received SLBZS combined with FOLFOX4 regi- men and the control group only accepted FOLFOX4 regimen. Results： Compared with the control group, the ad- verse reaction rate of treatment group significantly decreased （P〈0.05）, and the weight gain rate （64.3%） was obviously higher than that of control group （29.2%）. The number of lymphocyte conversion rate, complement C3, IgG, IgA, IgM raised in the treatment group was obviously higher than control group, and the values of CD4＋/ CD8＋ in the treatment group also higher than the control group （P〈0.05）, while the content of IL-6 and TNF-α dropped significantly （P〈0.05）. The total effective rate of traditional Chinese medicine syndromes of control group and treatment group were 70.8% and 92.9% respectively, with statistical significance （P〈0.05）. Conclusion： SLBZS can effectively reduce the adverse reaction; improve immune function and the quality of life.

关 键 词：胃癌 晚期 化疗 毒副反应 参苓白术散 免疫调节 

分 类 号：R273[医药卫生—中西医结合]