新型吡唑基取代的甲磺酰基类化合物的合成及除草活性研究  

Syntheses and Herbicidal Activities of New Methylsulfonyl Compounds with Pyrazol Group

作　　者：温彦鹏 张爽[2] 侯广峰[2] 于颖慧[1,2] 高金胜[1,2] 

机构地区：[1]黑龙江大学化学化工与材料学院,哈尔滨150080 [2]黑龙江大学农药工程中心,哈尔滨150080

出　　处：《有机化学》2016年第3期642-647,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21371052);黑龙江省博士后科研启动基金(No.LBH-Q14138)资助项目~~

摘　　要：为获得具有新颖结构和较高药效的新型除草剂,基于环磺酮的结构,对环磺酮结构中苯环的间位取代基及环己二酮环进行了修饰替换,设计了6个新型的含有吡唑基的甲磺酰基类杂环化合物.以2-甲基-3-氯苯胺起始原料,经重氮化、乙酰基化、两步氧化、酯化、溴化、亲核取代、氯化、缩合等9步反应最终获得6个目标化合物.最终产物以及重要中间体的结构采用~1H NMR、^(13)C NMR、FTIR、元素分析等方法进行表征与确认.对该6个化合物的除草活性进行了测试,结果表明各化合物对芥菜、繁缕、看麦娘、小藜、棒头草均表现出良好的除草效果.To obtain new herbicidal candidates with novel structure and high herbicidal activities, six new pyrazol compounds based on the structure of tembotrione were designed and synthesized. The meta substituent of benzene ring and the cyclohexadione ring in the original tembotrione structure are replaced. The six target compounds were achieved with 3-chloro-2-methylaniline as the starting material after nine steps reactions, namely diazotization, acetylization, oxidation, esterization, bromization, nucleophilic substitution, chlorination and condensation reactions. All the structures of target products and their intermediates are characterized and confirmed by ~1H NMR, ^（13）C NMR, FTIR and elemental analysis. Herbicidal activity tests are also conducted for the six compounds. The results show that each compound exhibits certain herbicidal activity toward mustard, chickweed, amur foxtail, chenopodium and polypogon fugax.

关 键 词：吡唑基 甲磺酰基 环磺酮 合成 反应条件 除草活性 

分 类 号：O626[理学—有机化学] TQ450.1[理学—化学]